(Q38946518)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25330774%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation (English)

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21 February 2020

0 references

1 reference

2

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21 February 2020

Saumel Ahmadi

3

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21 February 2020

author name string

Stan Pasyk

1

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21 February 2020

Mohabir Ramjeesingh

4

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21 February 2020

Ling-Jun Huan

5

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21 February 2020

Stephanie Chin

6

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21 February 2020

Kai Du

7

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21 February 2020

Herman Yeger

8

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21 February 2020

Paul Taylor

9

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21 February 2020

Michael F Moran

10

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21 February 2020

Christine E Bear

11

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21 February 2020

publication date

17 December 2014

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21 February 2020

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21 February 2020

volume

15

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21 February 2020

issue

2-3

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21 February 2020

page(s)

447-461

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Longitudinal analysis of pulmonary function decline in patients with cystic fibrosis

21 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

1 reference

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Evidence for airway surface dehydration as the initiating event in CF airway disease

21 January 2018

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Cystic Fibrosis: Lessons from the Sweat Gland

21 January 2018

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Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

21 January 2018

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Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis

21 January 2018

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Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

21 January 2018

1 reference

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Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide‐binding domain 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

21 January 2018

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Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR

21 January 2018

1 reference

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Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Phosphorylation of CFTR by PKA promotes binding of the regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Gating of CFTR by the STAS domain of SLC26 transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Relative respiratory syncytial virus cytopathogenesis in upper and lower respiratory tract epithelium

21 January 2018

1 reference

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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

21 January 2018

1 reference

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Assessment of clinical response to ivacaftor with lung clearance index in cystic fibrosis patients with a G551D-CFTR mutation and preserved spirometry: a randomised controlled trial

21 January 2018

1 reference

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Use of kinase inhibitors to correct ΔF508-CFTR function

21 January 2018

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A chemical corrector modifies the channel function of F508del-CFTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

Purification and reconstitution of epithelial chloride channel cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201400218

A novel procedure for the efficient purification of the cystic fibrosis transmembrane conductance regulator (CFTR)

21 January 2018

1 reference

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Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner

21 January 2018

1 reference

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Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection

21 January 2018

1 reference

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The intact CFTR protein mediates ATPase rather than adenylate kinase activity

21 January 2018

1 reference

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Trimmomatic: a flexible trimmer for Illumina sequence data

21 January 2018

1 reference

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Genetic, cell biological, and clinical interrogation of the CFTR mutation c.3700 A>G (p.Ile1234Val) informs strategies for future medical intervention.

21 January 2018

1 reference

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

21 January 2018

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Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence

21 January 2018

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A method for assessing the statistical significance of mass spectrometry-based protein identifications using general scoring schemes

21 January 2018

1 reference

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization

21 January 2018

1 reference

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Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulum

21 January 2018

1 reference

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Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions

21 January 2018

1 reference

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Cis-trans signatures of proline-containing tryptic peptides in the gas phase

21 January 2018

1 reference

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Post-translational modifications and their biological functions: proteomic analysis and systematic approaches

21 January 2018

1 reference

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Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/PMIC.201400218

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25330774%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference