(Q38977163)

8 September 2017

1 reference

title

P2X7 receptor antagonists: a patent review (2010-2015). (English)

1 reference

8 September 2017

Jin-Hee Park

1

1 reference

PubMed ID

27724045

8 September 2017

Yong-Chul Kim

series ordinal

2

1 reference

PubMed ID

27724045

8 September 2017

language of work or name

English

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publication date

10 October 2016

1 reference

Expert Opinion on Therapeutic Patents

8 September 2017

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8 September 2017

27

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8 September 2017

3

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8 September 2017

257-267

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https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

8 September 2017

1 reference

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Cellular localization of P2X7 receptor mRNA in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Tissue distribution of the P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

C terminus of the P2X7 receptor: treasure hunting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Regulation of phospholipase D by P2X7 receptors in submandibular ductal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Is pannexin the pore associated with the P2X7 receptor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

The P2X7 receptor: a key player in IL-1 processing and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Purinergic signalling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Targeting P2X₇ receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

P2X7 mediates ATP-driven invasiveness in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Over-expression of P2X7 receptors in spinal glial cells contributes to the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR) in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [¹¹C]A-740003 as a novel tracer of neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13543776.2017.1246538

10.1080/13543776.2017.1246538

21 January 2018

Identifiers

DOI

1 reference

8 September 2017

1 reference

PubMed ID

27724045