(Q39004496)

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A binuclear gold(I) complex with mixed bridging diphosphine and bis(N-heterocyclic carbene) ligands shows favorable thiol reactivity and inhibits tumor growth and angiogenesis in vivo.

scientific article published on 11 April 2014

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14 March 2020

A binuclear gold(I) complex with mixed bridging diphosphine and bis(N-heterocyclic carbene) ligands shows favorable thiol reactivity and inhibits tumor growth and angiogenesis in vivo (English)

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14 March 2020

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14 March 2020

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Ching Tung Lum

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14 March 2020

Chun-Nam Lok

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Chi-Ming Che

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11 April 2014

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14 March 2020

Angewandte Chemie International Edition

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14 March 2020

5810-5814

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14 March 2020

Carbene complexes of gold: preparation, medical application and bonding

1 reference

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Beyond catalysis: N-heterocyclic carbene complexes as components for medicinal, luminescent, and functional materials applications

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Stable cyclic carbenes and related species beyond diaminocarbenes

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Stable singlet carbenes as mimics for transition metal centers.

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The development and catalytic uses of N-heterocyclic carbene gold complexes

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N-Heterocyclic carbene transition metal complexes for catalysis in aqueous media

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A continuum of progress: applications of N-hetereocyclic carbene catalysis in total synthesis

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N-heterocyclic carbene gold(I) and copper(I) complexes in C-H bond activation

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The medicinal applications of imidazolium carbene-metal complexes

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Fascinating frontiers of N/O-functionalized N-heterocyclic carbene chemistry: from chemical catalysis to biomedical applications.

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Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

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N-Heterocyclic carbene metal complexes in medicinal chemistry

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Metal/N-heterocyclic carbene complexes: opportunities for the development of anticancer metallodrugs.

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21 January 2018

Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

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Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity.

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21 January 2018

Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

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Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes.

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Mitochondria-targeted chemotherapeutics: the rational design of gold(I) N-heterocyclic carbene complexes that are selectively toxic to cancer cells and target protein selenols in preference to thiols.

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21 January 2018

Targeting proteins with metal complexes

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Metal complexes in medicine with a focus on enzyme inhibition

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Organometallic anticancer compounds

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Gold compounds as therapeutic agents for human diseases

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21 January 2018

Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment

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21 January 2018

Molecular mechanisms and proposed targets for selected anticancer gold compounds

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21 January 2018

On the biological properties of alkynyl phosphine gold(I) complexes.

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21 January 2018

Next-generation metal anticancer complexes: multitargeting via redox modulation

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Gold(III) complexes containing N-heterocyclic carbene ligands: thiol "switch-on" fluorescent probes and anti-cancer agents.

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21 January 2018

In vivo and in vitro cardiotoxicity of a gold-containing antineoplastic drug candidate in the rabbit.

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21 January 2018

Gold-Based Therapeutic Agents: A New Perspective

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In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.

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21 January 2018

A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells

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21 January 2018

Antitumor activity of diethynylfluorene derivatives of gold(I).

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Gold(I) complex of N,N'-disubstituted cyclic thiourea with in vitro and in vivo anticancer properties-potent tight-binding inhibition of thioredoxin reductase

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Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

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21 January 2018

Dinuclear gold(I) complexes of bridging bidentate carbene ligands: synthesis, structure and spectroscopic characterisation

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Cell-specific, activatable, and theranostic prodrug for dual-targeted cancer imaging and therapy

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Inhibition of 1,4-beta-D-xylan xylanohydrolase by the specific aspartic protease inhibitor pepstatin: probing the two-step inhibition mechanism

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Gold ion-angiotensin peptide interaction by mass spectrometry

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Tumour stem cells and drug resistance

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Tunable cytotoxicity of rhodamine 6G via anion variations.

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A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.

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Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

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Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

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Identifiers

10.1002/ANIE.201400142

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24729298%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24729298%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

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