(Q39019427)

8 September 2017

Exploring allosteric coupling in the alpha-subunit of heterotrimeric G proteins using evolutionary and ensemble-based approaches (English)

1 reference

ORCID Public Data File 2021

8 September 2017

1 reference

author name string

Kemal Sayar

1

1 reference

8 September 2017

Ozlem Uğur

2

1 reference

8 September 2017

Tong Liu

3

1 reference

8 September 2017

Vincent J Hilser

4

1 reference

8 September 2017

Ongun Onaran

5

1 reference

8 September 2017

2 May 2008

1 reference

8 September 2017

BMC Structural Biology

1 reference

8 September 2017

8

1 reference

8 September 2017

23

1 reference

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

8 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structural basis of function in heterotrimeric G proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

A statistical thermodynamic model of the protein ensemble

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Ensemble-based signatures of energy propagation in proteins: a new view of an old phenomenon.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Natural-like function in artificial WW domains

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Analysis of the "thermodynamic information content" of a Homo sapiens structural database reveals hierarchical thermodynamic organization

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

AGS proteins, GPR motifs and the signals processed by heterotrimeric G proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Mapping pathways of allosteric communication in GroEL by analysis of correlated mutations

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Effective use of sequence correlation and conservation in fold recognition

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Evolutionarily conserved pathways of energetic connectivity in protein families

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Crystal structure of the adenylyl cyclase activator Gsalpha

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

The 2.0 A crystal structure of a heterotrimeric G protein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Can three-dimensional contacts in protein structures be predicted by analysis of correlated mutations?

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Conformational substates in proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Guanine nucleotide exchange-independent activation of Gs protein by beta2-adrenoceptor.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

On evolutionary conservation of thermodynamic coupling in proteins

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Theoretical study of the electrostatically driven step of receptor-G protein recognition

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Structure-based calculation of the equilibrium folding pathway of proteins. Correlation with hydrogen exchange protection factors.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Mutations at the domain interface of GSalpha impair receptor-mediated activation by altering receptor and guanine nucleotide binding

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Agonist efficacy and allosteric models of receptor action.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Prediction of an inter-residue interaction in the chaperonin GroEL from multiple sequence alignment is confirmed by double-mutant cycle analysis.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422842

Predicting the equilibrium protein folding pathway: structure-based analysis of staphylococcal nuclease

21 August 2018

1 reference

12 December 2020

Detection and reduction of evolutionary noise in correlated mutation analysis

1 reference

12 December 2020

Rhodopsin activation follows precoupling with transducin: inferences from computational analysis

1 reference

12 December 2020

Allostery without conformational change. A plausible model

1 reference

12 December 2020

Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins

1 reference

12 December 2020

Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States

1 reference

12 December 2020

Identifiers

DOI

10.1186/1472-6807-8-23

1 reference

Dimensions Publication ID

8 September 2017

0 references

1 reference

8 September 2017

PubMed publication ID

18454845

1 reference