(Q39032373)

English

Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans.

scientific article published on 3 March 2015

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scholarly article

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2 March 2020

Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans (English)

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2 March 2020

Caenorhabditis elegans

0 references

5

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2 March 2020

Young Joon Kwon

6

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2 March 2020

10

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2 March 2020

author name string

Shana McCormack

1

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2 March 2020

Erzsebet Polyak

2

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2 March 2020

Julian Ostrovsky

3

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2 March 2020

Stephen D Dingley

4

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2 March 2020

Rui Xiao

7

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2 March 2020

Zhe Zhang

8

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2 March 2020

Eiko Nakamaru-Ogiso

9

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2 March 2020

publication date

3 March 2015

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2 March 2020

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2 March 2020

22

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2 March 2020

45-59

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2 March 2020

Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation

1 reference

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9 September 2017

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans

1 reference

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9 September 2017

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

1 reference

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9 September 2017

Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

PPARγ signaling and metabolism: the good, the bad and the future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1.

1 reference

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9 September 2017

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Sirtuins as regulators of metabolism and healthspan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Fluorescence-activated cell sorting analysis of mitochondrial content, membrane potential, and matrix oxidant burden in human lymphoblastoid cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Stable isotopic profiling of intermediary metabolic flux in developing and adult stage Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Endogenous ligands for nuclear receptors: digging deeper

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Regulation of SIRT1 in cellular functions: role of polyphenols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Molecular and sensory basis of a food related two-state behavior in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

The in-depth evaluation of suspected mitochondrial disease

1 reference

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9 September 2017

Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Worming pathways to and from DAF-16/FOXO.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae

1 reference

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Mitochondrial encephalomyopathies: an update

1 reference

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Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

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1 reference

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9 September 2017

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

1 reference

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9 September 2017

Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

9 September 2017

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

14 September 2017

Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

14 September 2017

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1.

1 reference

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17 June 2018

Role of resveratrol in FOXO1-mediated gluconeogenic gene expression in the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

17 June 2018

Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447550

17 June 2018

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

1 reference

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17 June 2018

Practice patterns of mitochondrial disease physicians in North America. Part 1: diagnostic and clinical challenges

1 reference

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21 August 2018

Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid.

1 reference

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21 August 2018

Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.

1 reference

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21 August 2018

Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

1 reference

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21 August 2018

Mitochondrial expression and function of GAS-1 in Caenorhabditis elegans

1 reference

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21 August 2018

Induction of serum: pyruvate aminotransferase in rat liver organelles by glucagon and a high-protein diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/25744875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/25744875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flux of the L-serine metabolism in rabbit, human, and dog livers. Substantial contributions of both mitochondrial and peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25744875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C. elegans sirtuins

1 reference

https://pubmed.ncbi.nlm.nih.gov/25744875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic effects of imidazolium-based ionic liquids on Caenorhabditis elegans: the role of reactive oxygen species

1 reference

https://pubmed.ncbi.nlm.nih.gov/25744875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MITO.2015.02.005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25744875%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25744875%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25744875%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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