(Q39033190)

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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

scientific article published on 5 January 2017

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Europe PubMed Central

PubMed publication ID

8 September 2017

An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs (English)

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Europe PubMed Central

PubMed publication ID

8 September 2017

author name string

Michael K Pugsley

1

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Europe PubMed Central

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8 September 2017

Brian Guth

2

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8 September 2017

Alan Y Chiang

3

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8 September 2017

Jennifer M Doyle

4

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8 September 2017

Michael Engwall

5

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8 September 2017

Jean-Michel Guillon

6

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8 September 2017

Peter K Hoffmann

7

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8 September 2017

John E Koerner

8

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8 September 2017

Scott W Mittelstadt

9

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8 September 2017

Jennifer Beck Pierson

10

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8 September 2017

Eric I Rossman

11

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8 September 2017

Dustan R Sarazan

12

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8 September 2017

Stanley T Parish

13

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8 September 2017

publication date

5 January 2017

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8 September 2017

Journal of Pharmacological and Toxicological Methods

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8 September 2017

85

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8 September 2017

1-21

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8 September 2017

QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: model optimisation and evaluation.

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Congestive heart failure associated with itraconazole

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Time constants of cardiac function and their calculations

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Evaluation of the QA interval as an index of cardiac contractility in anaesthetised dogs: responses to changes in cardiac loading and heart rate.

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

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An approach to the assessment of drug-induced changes in non-electrophysiological properties of cardiovascular function

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dP/dt(max)--a measure of 'baroinometry'

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Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: invasive LVP measurements versus the QA interval.

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Clinical efficacy and safety of pimobendan in treatment of heart failure--experience in Japan

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Optimizing the experimental environment for dog telemetry studies.

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Amrinone metabolism

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Omecamtiv mecarbil: a new cardiac myosin activator for the treatment of heart failure

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Effects of changes in preload, afterload and inotropic state on ejection and isovolumic phase measures of contractility in the conscious dog

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7 January 2021

The value added by measuring myocardial contractility 'in vivo' in safety pharmacological profiling of drug candidates

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7 January 2021

Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole

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7 January 2021

Assessment of the pharmacological effects of inotropic drugs on left ventricular pressure and contractility: an evaluation of the QA interval as an indirect indicator of cardiac inotropism.

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7 January 2021

Itraconazole decreases left ventricular contractility in isolated rabbit heart: mechanism of action

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Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart

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7 January 2021

Cardiovascular pressure measurement in safety assessment studies: technology requirements and potential errors

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7 January 2021

Cardiovascular function in nonclinical drug safety assessment: current issues and opportunities

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7 January 2021

Left ventricular pressure, contractility and dP/dt(max) in nonclinical drug safety assessment studies

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7 January 2021

Isometric time-tension relationships as an index of myocardial contractility

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7 January 2021

Cardiovascular safety assessments in the conscious telemetered dog: utilisation of super-intervals to enhance statistical power

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7 January 2021

Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio.

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7 January 2021

Translational assessment of cardiac contractility by echocardiography in the telemetered rat.

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Differential cardiovascular effects of propranolol, atenolol, and pindolol measured by impedance cardiography

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Is tau a preload-independent measure of isovolumetric relaxation?

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Amrinone A Preliminary Review of its Pharmacological Properties and Therapeutic Use

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First Clinical Experience with ONO-4232: A Randomized, Double-blind, Placebo-controlled Healthy Volunteer Study of a Novel Lusitropic Agent for Acutely Decompensated Heart Failure

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7 January 2021

Identifiers

10.1016/J.VASCN.2017.01.002

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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