(Q39034996)

8 September 2017

title

Signal transduction mechanism of biased ligands at histamine H2 receptors (English)

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8 September 2017

Natalia Alonso

1

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8 September 2017

Federico Monczor

2

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8 September 2017

Emiliana Echeverría

3

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8 September 2017

Carlos Davio

4

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8 September 2017

Carina Shayo

5

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8 September 2017

Natalia Fernández

6

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8 September 2017

language of work or name

English

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publication date

1 April 2014

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8 September 2017

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8 September 2017

volume

459

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8 September 2017

issue

1

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8 September 2017

page(s)

117-126

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Desensitization of G protein-coupled receptors and neuronal functions

8 September 2017

cites work

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https://api.crossref.org/works/10.1042%2FBJ20131226

How many drug targets are there?

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Trends in the exploitation of novel drug targets

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Biased signalling and allosteric machines: new vistas and challenges for drug discovery

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

21 January 2018

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

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Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

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Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.

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Multiple ligand-specific conformations of the β2-adrenergic receptor

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A pharmacological primer of biased agonism

21 January 2018

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Consumer knowledge of over-the-counter phenazopyridine

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Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

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Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model

21 January 2018

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Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors

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Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization

21 January 2018

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"Ins and outs" of seven-transmembrane receptor signalling to ERK.

21 January 2018

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PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation

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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

21 January 2018

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Interaction of Ras with phosphoinositide 3-kinase gamma

21 January 2018

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G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling

21 January 2018

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

21 January 2018

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G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

21 January 2018

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Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent.

21 January 2018

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New roles for G-protein beta gamma-dimers in transmembrane signalling.

21 January 2018

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Receptor-effector coupling by G proteins

21 January 2018

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Does subunit dissociation necessarily accompany the activation of all heterotrimeric G proteins?

21 January 2018

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Conformational rearrangements and signaling cascades involved in ligand-biased mitogen-activated protein kinase signaling through the beta1-adrenergic receptor.

21 January 2018

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Agonist efficacy and allosteric models of receptor action.

21 January 2018

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The ligand paradox between affinity and efficacy: can you be there and not make a difference?

21 January 2018

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Beta-arrestin1 and beta-arrestin2 are differentially required for phosphorylation-dependent and -independent internalization of delta-opioid receptors

21 January 2018

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

21 January 2018

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Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

21 January 2018

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Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands.

21 January 2018

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Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2.

21 January 2018

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Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils

21 January 2018

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20131226

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8 September 2017

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