(Q39048659)

14 June 2018

title

Stromal Senescence By Prolonged CDK4/6 Inhibition Potentiates Tumor Growth (English)

1 reference

14 June 2018

author name string

Xiangnan Guan

1

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14 June 2018

Kyle M LaPak

2

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14 June 2018

Rebecca C Hennessey

3

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14 June 2018

Christina Y Yu

4

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14 June 2018

Reena Shakya

5

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14 June 2018

Jianying Zhang

6

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14 June 2018

Christin E Burd

7

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14 June 2018

publication date

30 December 2016

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14 June 2018

Molecular Cancer Research

published in

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14 June 2018

volume

15

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14 June 2018

issue

3

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14 June 2018

page(s)

237-249

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14 June 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5334447/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment

17 June 2018

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Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1).

17 June 2018

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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17 June 2018

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RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

17 June 2018

1 reference

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Oncogenic Braf induces melanocyte senescence and melanoma in mice

17 June 2018

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The inflammatory network: bridging senescent stroma and epithelial tumorigenesis

17 June 2018

1 reference

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Senescent stromal-derived osteopontin promotes preneoplastic cell growth

17 June 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

17 June 2018

1 reference

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Living on a break: cellular senescence as a DNA-damage response

17 June 2018

1 reference

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Cellular senescence: when bad things happen to good cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

17 June 2018

1 reference

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5334447

10.1158/1541-7786.MCR-16-0319

21 August 2018

Identifiers

DOI

1 reference

14 June 2018

PMCID

5334447

1 reference

14 June 2018

PubMed ID

28039358

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14 June 2018