(Q39062248)

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Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells

scientific article published on 16 November 2013

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Europe PubMed Central

PubMed publication ID

8 September 2017

Interleukin-6 inhibition of peroxisome proliferator-activated receptor alpha expression is mediated by JAK2- and PI3K-induced STAT1/3 in HepG2 hepatocyte cells (English)

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Europe PubMed Central

PubMed publication ID

8 September 2017

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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Guat-Siew Chew

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alexander Chong Shu-Chien

3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Tengku Sifzizul Tengku Muhammad

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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16 November 2013

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Europe PubMed Central

PubMed publication ID

8 September 2017

Molecular and Cellular Biochemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

388

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1-2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

25-37

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24242046%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

1 reference

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An alternative regulatory pathway of the acute phase response: the role of fibroblast-derived interferon-beta 2.

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Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors

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21 January 2018

Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate

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The acute phase response is associated with retinoid X receptor repression in rodent liver

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Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure

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Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response

1 reference

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Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors

1 reference

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Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha

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Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling

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IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells

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Prognostic significance of activated AKT expression in soft-tissue sarcoma.

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PI3K/Akt/mTOR pathway as a target for cancer therapy

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MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

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Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

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The effects of injury magnitude on the kinetics of the acute phase response

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21 January 2018

Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence

1 reference

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21 January 2018

Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

1 reference

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Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation

1 reference

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IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro

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The regulation of liver cell survival by complement

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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21 January 2018

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

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Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway

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PI3K and STAT3: a new alliance.

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Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins

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Structure, function, and regulation of STAT proteins

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Signal transducer and activator of transcription (stat) binding sites but not stat3 are required for fasting-induced transcription of agouti-related protein messenger ribonucleic acid

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Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats

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Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated

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The identification and characterization of a STAT 1 binding site in the PPARgamma2 promoter

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Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes.

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1 reference

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

Differential role of Jak-STAT signaling in retinal degenerations

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24242046

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1 reference

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inferred from PubMed ID database lookup

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

1 reference

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inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

Stats: transcriptional control and biological impact

1 reference

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24242046

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inferred from PubMed ID database lookup

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24242046

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inferred from PubMed ID database lookup

SOCS3 in liver regeneration and hepatocarcinoma

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

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