(Q39079705)

8 September 2017

title

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro (English)

1 reference

8 September 2017

0 references

Shoichi Kaneshiro

1

1 reference

8 September 2017

Kosuke Ebina

2

1 reference

8 September 2017

Kenrin Shi

3

1 reference

8 September 2017

Chikahisa Higuchi

4

1 reference

8 September 2017

Makoto Hirao

5

1 reference

8 September 2017

Michio Okamoto

6

1 reference

8 September 2017

Kota Koizumi

7

1 reference

8 September 2017

Tokimitsu Morimoto

8

1 reference

8 September 2017

Hideki Yoshikawa

9

1 reference

8 September 2017

Jun Hashimoto

10

1 reference

8 September 2017

publication date

1 July 2014

1 reference

Journal of Bone and Mineral Metabolism

8 September 2017

published in

1 reference

8 September 2017

volume

32

1 reference

8 September 2017

issue

4

1 reference

8 September 2017

page(s)

378-392

1 reference

The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis

8 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Inhibition of IL-6 for the treatment of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Interleukin 6 plays a key role in the development of antigen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

The paradigm of IL-6: from basic science to medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

The role of the interleukin‐6 family of cytokines in inflammatory arthritis and bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Interleukin-6: An osteotropic factor influencing bone formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Molecular basis of the cell specificity of cytokine action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

In vitro differentiation profile of osteoblasts derived from patients with Saethre-Chotzen syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Akt1 in osteoblasts and osteoclasts controls bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Increased bone formation in osteocalcin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Role of mitogen‐activated protein kinase in osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Ras-MAPK signaling in osteogenic differentiation: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Rheumatoid arthritis synoviocyte survival is dependent on Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-013-0514-1

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

21 January 2018

1 reference

12 December 2020

Interleukin-6 inhibits bone formation in vitro

1 reference

12 December 2020

Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis

1 reference

12 December 2020

Effects of interleukin-6 on the metabolism of connective tissue components in rheumatoid synovial fibroblasts

1 reference

12 December 2020

c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling

1 reference

12 December 2020

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation

1 reference

12 December 2020

Extracellular-signal regulated kinase signaling pathway mediates downregulation of type I procollagen gene expression by FGF-2, PDGF-BB, and okadaic acid in osteoblastic cells

1 reference

12 December 2020

Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudy

1 reference

12 December 2020

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

1 reference

12 December 2020

Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis

1 reference

12 December 2020

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

12 December 2020

The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses.

1 reference

12 December 2020

Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter

1 reference

12 December 2020

Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage.

1 reference

12 December 2020

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

1 reference

12 December 2020

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

1 reference

12 December 2020

Akt1 regulates phosphorylation and osteogenic activity of Dlx3

1 reference

12 December 2020

10.1007/S00774-013-0514-1

Identifiers

DOI

1 reference

8 September 2017

1 reference