(Q39093085)

English

Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties.

scientific article published on 2 November 2016

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scholarly article

1 reference

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30 March 2020

Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27987228%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

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pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

1

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30 March 2020

author name string

Justin L Hay

2

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30 March 2020

Elske Sitsen

3

1 reference

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30 March 2020

Albert Dahan

4

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30 March 2020

Erica Klaassen

5

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30 March 2020

William Houghton

6

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30 March 2020

Geert Jan Groeneveld

7

1 reference

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30 March 2020

language of work or name

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publication date

16 December 2016

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30 March 2020

British Journal of Clinical Pharmacology

1 reference

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30 March 2020

83

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30 March 2020

4

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30 March 2020

751-763

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27987228%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

The Concise Guide to PHARMACOLOGY 2015/16: Transporters

1 reference

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15 June 2018

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

1 reference

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15 June 2018

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

1 reference

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Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy

1 reference

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Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

1 reference

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15 June 2018

Clinical pharmacology of analgesics assessed with human experimental pain models: bridging basic and clinical research

1 reference

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15 June 2018

Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs

1 reference

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Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review

1 reference

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15 June 2018

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Effects of intrathecal ketorolac on human experimental pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans

1 reference

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15 June 2018

Effectiveness and safety of postoperative pain management: a survey of 18 925 consecutive patients between 1998 and 2006 (2nd revision): a database analysis of prospectively raised data

1 reference

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15 June 2018

Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans

1 reference

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15 June 2018

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Antidepressants in the treatment of neuropathic pain

2 references

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15 June 2018

https://api.crossref.org/works/10.1111%2FBCP.13176

21 January 2018

Simultaneous measurement and integrated analysis of analgesia and respiration after an intravenous morphine infusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Principles and applicability of CSF sampling for the assessment of CNS drug delivery and pharmacodynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Isolation and characterization of a novel conus peptide with apparent antinociceptive activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

1 reference

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15 June 2018

alpha(2)-adrenergic agonists for regional anesthesia. A clinical review of clonidine (1984-1995).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Morphine and ibuprofen compared using the cold pressor test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

15 June 2018

Post-lumbar puncture headaches: experience in 501 consecutive procedures

1 reference

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15 June 2018

Tapentadol immediate release: a review of its use in the treatment of moderate to severe acute pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

17 June 2018

Intrathecal sufentanil is more potent than intravenous for postoperative analgesia after total-hip replacement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

17 June 2018

Analgesic and sympatholytic effects of low-dose intrathecal clonidine compared with bupivacaine: a dose-response study in female volunteers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

21 August 2018

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

21 August 2018

Spinal anaesthesia for elective surgery: a comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine

1 reference

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21 August 2018

Effects of gabapentin on experimental somatic pain and temporal summation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

21 August 2018

Alfentanil and placebo analgesia: no sex differences detected in models of experimental pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

21 August 2018

Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5346871

21 August 2018

Pressure-pain function in desensitized and hypersensitized muscle and skin assessed by cuff algometry

1 reference

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Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

1 reference

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21 August 2018

Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged.

1 reference

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21 August 2018

chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter

1 reference

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21 August 2018

The transfer half-life of morphine-6-glucuronide from plasma to effect site assessed by pupil size measurement in healthy volunteers

1 reference

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21 August 2018

Comparison of five experimental pain tests to measure analgesic effects of alfentanil

1 reference

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21 August 2018

The analgesic effect of codeine as compared to imipramine in different human experimental pain models

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal cyclooxygenase inhibitors in humans: don't throw in the towel!

1 reference

https://pubmed.ncbi.nlm.nih.gov/27987228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-Modal and Tissue-Differentiated Experimental Pain Assessment: Reproducibility of a New Concept for Assessment of Analgesics

1 reference

https://pubmed.ncbi.nlm.nih.gov/27987228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BCP.13176

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27987228%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27987228%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27987228%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

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