(Q39109844)

English

Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network

scientific article published on October 2006

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Statements

scholarly article

1 reference

Europe PubMed Central

9 September 2017

Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network (English)

1 reference

Europe PubMed Central

9 September 2017

transmembrane transport

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Escherichia coli

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transmembrane protein

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author name string

Yumiko Takatsuka

1

1 reference

Europe PubMed Central

9 September 2017

Hiroshi Nikaido

2

1 reference

Europe PubMed Central

9 September 2017

language of work or name

0 references

publication date

1 October 2006

1 reference

Europe PubMed Central

9 September 2017

Journal of Bacteriology

1 reference

Europe PubMed Central

9 September 2017

188

1 reference

Europe PubMed Central

9 September 2017

20

1 reference

Europe PubMed Central

9 September 2017

7284-7289

1 reference

Europe PubMed Central

9 September 2017

Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Microbial selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Multidrug-exporting secondary transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Structure and mechanism of the lactose permease of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Crystal structure of bacterial multidrug efflux transporter AcrB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Analysis of a complete library of putative drug transporter genes in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Cys-scanning mutagenesis: a novel approach to structure function relationships in polytopic membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Proton-dependent multidrug efflux systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Cross-linked complex between oligomeric periplasmic lipoprotein AcrA and the inner-membrane-associated multidrug efflux pump AcrB from Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

9 September 2017

Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

14 September 2017

Conformational changes in the multidrug transporter EmrE associated with substrate binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

15 June 2018

AcrA is a highly asymmetric protein capable of spanning the periplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

15 June 2018

Antibiotic resistance caused by gram-negative multidrug efflux pumps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

15 June 2018

Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

15 June 2018

Interactions underlying assembly of the Escherichia coli AcrAB-TolC multidrug efflux system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

Direct evidence for substrate-induced proton release in detergent-solubilized EmrE, a multidrug transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

An ABC transporter with a secondary-active multidrug translocator domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1636234

21 August 2018

Mutant membrane protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17015667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energetics and topology of CzcA, a cation/proton antiporter of the resistance-nodulation-cell division protein family

1 reference

https://pubmed.ncbi.nlm.nih.gov/17015667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JB.00683-06

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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