(Q39128275)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25226087%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38 (English)

1 reference

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16 February 2020

3

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16 February 2020

author name string

Joanna M Swarbrick

1

1 reference

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16 February 2020

Richard Graeff

2

1 reference

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16 February 2020

Mark P Thomas

4

1 reference

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16 February 2020

Quan Hao

5

1 reference

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16 February 2020

Barry V L Potter

6

1 reference

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16 February 2020

language of work or name

English

0 references

publication date

1 October 2014

1 reference

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Journal of Medicinal Chemistry

16 February 2020

published in

1 reference

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16 February 2020

volume

57

1 reference

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16 February 2020

issue

20

1 reference

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16 February 2020

page(s)

8517-8529

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25226087%20AND%20SRC:MED&resulttype=core&format=json

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template

16 February 2020

cites work

1 reference

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CD38 and chronic lymphocytic leukemia: a decade later

9 September 2017

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Design, synthesis and biological characterization of novel inhibitors of CD38.

9 September 2017

1 reference

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The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells

9 September 2017

1 reference

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Features and development of Coot

9 September 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

9 September 2017

1 reference

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Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38

9 September 2017

1 reference

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Phasercrystallographic software

9 September 2017

1 reference

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CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Crystal structure of human CD38 extracellular domain

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Refinement of macromolecular structures by the maximum-likelihood method

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

The CCP4 suite: programs for protein crystallography

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Medicinal chemistry and pharmacology of cyclic ADP-ribose

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Biochemistry, biology, and pharmacology of cyclic adenosine diphosphoribose (cADPR)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Syntheses and calcium-mobilizing evaluations of N1-glycosyl-substituted stable mimics of cyclic ADP-ribose

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Development and validation of a genetic algorithm for flexible docking

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

The crystal structure of cyclic ADP-ribose

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

The membrane-bound enzyme CD38 exists in two opposing orientations

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Total synthesis of a cyclic adenosine 5'-diphosphate ribose receptor agonist

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Probing the catalytic mechanism of bovine CD38/NAD+ glycohydrolase by site directed mutagenesis of key active site residues.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

CD38 is critical for social behaviour by regulating oxytocin secretion

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Decreased cADPR and increased NAD+ in the Cd38-/- mouse.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Regulation of intracellular levels of NAD: a novel role for CD38.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5'-diphosphate ribose analogue.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Rapid synthetic route toward structurally modified derivatives of cyclic adenosine 5'-diphosphate ribose

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

A minimal structural analogue of cyclic ADP-ribose: synthesis and calcium release activity in mammalian cells

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Synthesis and biological evaluation of novel membrane-permeant cyclic ADP-ribose mimics: N1-[(5''-O-phosphorylethoxy)methyl]-5'-O-phosphorylinosine 5',5''-cyclicpyrophosphate (cIDPRE) and 8-substituted derivatives

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Novel hydrolysis-resistant analogues of cyclic ADP-ribose: modification of the "northern" ribose and calcium release activity

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Total synthesis of cyclic ADP-carbocyclic-ribose, a stable mimic of Ca2+-mobilizing second messenger cyclic ADP-ribose

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207131

Identification of the enzymatic active site of CD38 by site-directed mutagenesis

21 August 2018

1 reference

12 December 2020

An efficient synthesis of cyclic IDP- and cyclic 8-bromo-IDP-carbocyclic-riboses using a modified Hata condensation method to form an intramolecular pyrophosphate linkage as a key step. An entry to a general method for the chemical synthesis of cycl

1 reference

12 December 2020

A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities

1 reference

12 December 2020

The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid

1 reference

12 December 2020

Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis

1 reference

12 December 2020

Flavonoids as inhibitors of human CD38

1 reference

12 December 2020

Design, synthesis and biological evaluation of noncovalent inhibitors of human CD38 NADase

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Position of cyclization in cyclic ADP-ribose

1 reference

12 December 2020

Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases

1 reference

12 December 2020

Fluorescent analogs of cyclic ADP-ribose: synthesis, spectral characterization, and use

1 reference

12 December 2020

Cyclic aristeromycin diphosphate ribose: a potent and poorly hydrolysable Ca(2+)-mobilising mimic of cyclic adenosine diphosphate ribose

1 reference

12 December 2020

Roles for adenosine ribose hydroxyl groups in cyclic adenosine 5'-diphosphate ribose-mediated Ca2+ release

1 reference

12 December 2020

The reaction mechanism for CD38. A single intermediate is responsible for cyclization, hydrolysis, and base-exchange chemistries

1 reference

12 December 2020

The Role of Polyamines in the Neutralization of Bacteriophage Deoxyribonucleic Acid

1 reference

19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)67936-6

Identifiers

DOI

10.1021/JM501037U

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25226087%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25226087%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

PubMed publication ID

25226087

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25226087%20AND%20SRC:MED&resulttype=core&format=json