(Q39136404)

9 September 2017

title

A signal transduction pathway from TGF-β1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma (English)

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9 September 2017

Xuan Qu

1

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9 September 2017

Liangliang Shen

2

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9 September 2017

Yan Zheng

3

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9 September 2017

Yang Cui

4

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9 September 2017

Zhihui Feng

5

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9 September 2017

Feng Liu

6

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9 September 2017

Jiankang Liu

7

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9 September 2017

language of work or name

English

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publication date

21 June 2013

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Journal of Investigative Dermatology

9 September 2017

published in

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9 September 2017

volume

134

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9 September 2017

issue

1

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9 September 2017

page(s)

159-167

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https://scigraph.springernature.com/pub.10.1038/jid.2013.281

9 September 2017

exact match

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cites work

Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells

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12 December 2020

Transforming growth factor-beta in cutaneous melanoma

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12 December 2020

Glypican-1 stimulates Skp2 autoinduction loop and G1/S transition in endothelial cells

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12 December 2020

Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

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12 December 2020

TGF-beta and epithelial-to-mesenchymal transitions

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12 December 2020

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

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12 December 2020

Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors

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12 December 2020

A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia

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12 December 2020

Skp2 and p27kip1 expression in melanocytic nevi and melanoma: an inverse relationship

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12 December 2020

C-myc oncogene expression in human melanoma and its relationship with tumour antigenicity

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12 December 2020

SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.

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12 December 2020

Functional and therapeutic significance of Akt deregulation in malignant melanoma.

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12 December 2020

The basics of epithelial-mesenchymal transition

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12 December 2020

Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

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12 December 2020

A reciprocal relationship between Rb and Skp2: implications for restriction point control, signal transduction to the cell cycle and cancer

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12 December 2020

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12 December 2020

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

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12 December 2020

Amplification and overexpression of SKP2 are associated with metastasis of non-small-cell lung cancers to lymph nodes

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12 December 2020

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.

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12 December 2020

Regulation of the cell cycle by SCF-type ubiquitin ligases

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12 December 2020

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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12 December 2020

Acetylation-dependent regulation of Skp2 function

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12 December 2020

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

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12 December 2020

Skp2 regulates Myc protein stability and activity

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12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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12 December 2020

Biomarkers for epithelial-mesenchymal transitions

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12 December 2020

MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis

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12 December 2020

The ubiquitin-specific protease USP28 is required for MYC stability

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12 December 2020

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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12 December 2020

NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity.

1 reference

12 December 2020

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

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12 December 2020

Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells

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12 December 2020

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

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12 December 2020

Clinical relevance of SKP2 alterations in metastatic melanoma

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12 December 2020

Influence of increased c-Myc expression on the growth characteristics of human melanoma

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12 December 2020

WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells

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12 December 2020

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

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12 December 2020

Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

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12 December 2020

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

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12 December 2020

A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition

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12 December 2020

Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

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12 December 2020

Rapamycin resistance is linked to defective regulation of Skp2.

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12 December 2020

Identifiers

DOI

10.1038/JID.2013.281

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9 September 2017

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