(Q39140690)

9 September 2017

title

Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling (English)

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9 September 2017

Shu-Ping Song

1

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9 September 2017

Anne Hennig

2

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9 September 2017

Katja Schubert

3

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9 September 2017

Robby Markwart

4

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9 September 2017

Philipp Schmidt

5

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9 September 2017

Ian A Prior

6

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9 September 2017

Frank-Dietmar Böhmer

7

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9 September 2017

Ignacio Rubio

8

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9 September 2017

language of work or name

English

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publication date

1 September 2013

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9 September 2017

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9 September 2017

volume

454

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9 September 2017

issue

2

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9 September 2017

page(s)

323-332

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Regulating the regulator: post-translational modification of RAS

9 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Activation of the MAPK module from different spatial locations generates distinct system outputs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Spatial segregation of Ras signaling: new evidence from fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

A permissive function of phosphoinositide 3-kinase in Ras activation mediated by inhibition of GTPase-activating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras isoform abundance and signalling in human cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Nonradioactive determination of Ras-GTP levels using activated ras interaction assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras-dependent activation of the small GTPase Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Activation of the MAP kinase pathway by the protein kinase raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras oncogenes: split personalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Using cells devoid of RAS proteins as tools for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Raft protein clustering alters N-Ras membrane interactions and activation pattern.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Ras trafficking, localization and compartmentalized signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

The spread of Ras activity triggered by activation of a single dendritic spine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Signalling ballet in space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

A novel switch region regulates H-ras membrane orientation and signal output

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Palmitoylation of oncogenic NRAS is essential for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

SIGNAL TRANSDUCTION: Prelude to an Anniversary for the RAS Oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20121799

21 January 2018

Identifiers

DOI

10.1042/BJ20121799

1 reference

release_5ff7m5tykffw5brvkicupdojly

9 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5ff7m5tykffw5brvkicupdojly

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference