(Q39141673)

English

Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276.

scientific article published on 11 June 2013

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scholarly article

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Europe PubMed Central

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2 March 2020

Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276 (English)

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2 March 2020

multiple myeloma

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based on heuristic

inferred from title

Rodger Tiedemann

7

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2 March 2020

author name string

J Schmidt

1

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2 March 2020

E Braggio

2

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2 March 2020

K M Kortuem

3

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2 March 2020

J B Egan

4

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2 March 2020

Y X Zhu

5

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2 March 2020

C S Xin

6

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2 March 2020

S E Palmer

8

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2 March 2020

V M Garbitt

9

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2 March 2020

D McCauley

10

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2 March 2020

M Kauffman

11

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2 March 2020

S Shacham

12

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2 March 2020

M Chesi

13

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2 March 2020

P L Bergsagel

14

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2 March 2020

A K Stewart

15

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2 March 2020

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publication date

11 June 2013

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2 March 2020

1 reference

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2 March 2020

27

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2 March 2020

2357-2365

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2 March 2020

12

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2 March 2020

https://scigraph.springernature.com/pub.10.1038/leu.2013.172

0 references

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Development of Proteasome Inhibitors as Therapeutic Drugs

1 reference

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10 September 2017

Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

NESdb: a database of NES-containing CRM1 cargoes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia

1 reference

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10 September 2017

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

1 reference

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10 September 2017

Nuclear export of proteins and drug resistance in cancer

1 reference

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10 September 2017

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

1 reference

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10 September 2017

CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase

1 reference

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10 September 2017

Improved survival in multiple myeloma and the impact of novel therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

1 reference

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10 September 2017

Distinguishing primary and secondary translocations in multiple myeloma

1 reference

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10 September 2017

Molecular pathogenesis and a consequent classification of multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3922416

10 September 2017

Multiple myeloma: evolving genetic events and host interactions

1 reference

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10 September 2017

Pathways governing G1/S transition and their response to DNA damage

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Phase I trial of elactocin

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10 September 2017

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

1 reference

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10 September 2017

Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome

1 reference

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1 reference

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25 September 2017

The expression of CRM1 is associated with prognosis in human osteosarcoma

1 reference

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Recent major improvement in long-term survival of younger patients with multiple myeloma

1 reference

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21 August 2018

Prognostic value of CRM1 in pancreas cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23752175

12 December 2020

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10.1038/LEU.2013.172

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2 March 2020

1 reference

Europe PubMed Central

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2 March 2020

1 reference

Europe PubMed Central

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2 March 2020

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