(Q39203918)

10 September 2017

title

Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1. (English)

1 reference

10 September 2017

1 reference

L Mirandola

1

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10 September 2017

L Apicella

2

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10 September 2017

M Colombo

3

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10 September 2017

Y Yu

4

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10 September 2017

D G Berta

5

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10 September 2017

N Platonova

6

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10 September 2017

E Lazzari

7

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10 September 2017

M Lancellotti

8

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10 September 2017

G Bulfamante

9

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10 September 2017

E Cobos

10

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10 September 2017

M Chiriva-Internati

11

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10 September 2017

R Chiaramonte

12

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10 September 2017

publication date

28 January 2013

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10 September 2017

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10 September 2017

volume

27

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10 September 2017

issue

7

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10 September 2017

page(s)

1558-1566

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Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

10 September 2017

cites work

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21 January 2018

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21 January 2018

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Advances in the understanding of myeloma bone disease and tumour growth

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Notch-ing from T-cell to B-cell lymphoid malignancies.

21 January 2018

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Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients.

21 January 2018

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Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

21 January 2018

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Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

21 January 2018

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Chemokines in multiple myeloma

21 January 2018

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Integrin alpha4beta1 involvement in stromal cell-derived factor-1alpha-promoted myeloma cell transendothelial migration and adhesion: role of cAMP and the actin cytoskeleton in adhesion.

21 January 2018

1 reference

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Notch and the immune system.

21 January 2018

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Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma

21 January 2018

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Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

21 January 2018

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Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

21 January 2018

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Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma

21 January 2018

1 reference

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Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

21 January 2018

1 reference

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Notch inhibition blocks multiple myeloma cell-induced osteoclast activation

21 January 2018

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Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice

21 January 2018

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Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells

21 January 2018

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A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes.

21 January 2018

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CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia

21 January 2018

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Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro

21 January 2018

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CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

21 January 2018

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

21 January 2018

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Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy

21 January 2018

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Galectin-3C inhibits tumor growth and increases the anticancer activity of bortezomib in a murine model of human multiple myeloma

21 January 2018

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

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Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events

21 January 2018

1 reference

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Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

21 January 2018

1 reference

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Direct inhibition of the NOTCH transcription factor complex

21 January 2018

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Multiple myeloma: chemotherapy or transplantation in the era of new drugs.

21 January 2018

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Treatment of relapsed and refractory myeloma

21 January 2018

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Novel therapeutic targets for multiple myeloma

21 January 2018

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The molecular characterization and clinical management of multiple myeloma in the post-genome era.

21 January 2018

1 reference

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Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Induction of chemokine receptor expression during early stages of T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2013.27

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

7 January 2021

Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

7 January 2021

Immunohistochemical analysis of NOTCH1 and JAGGED1 expression in multiple myeloma and monoclonal gammopathy of undetermined significance

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

7 January 2021

Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

7 January 2021

Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.27

7 January 2021

Identifiers

DOI

10.1038/LEU.2013.27

1 reference

10 September 2017

1 reference