(Q39243281)

English

Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells

scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Novel role for pendrin in orchestrating bicarbonate secretion in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing airway serous cells (English)

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

cystic fibrosis

0 references

transmembrane protein

0 references

author name string

James P Garnett

1

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Emma Hickman

2

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Rachel Burrows

3

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Péter Hegyi

4

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

László Tiszlavicz

5

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Alan W Cuthbert

6

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Peying Fong

7

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

Michael A Gray

8

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

language of work or name

0 references

publication date

13 September 2011

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

number of pages

14

1 reference

based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

286

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

47

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

41069-41082

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

A new role for bicarbonate in mucus formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Mucus secretion from individual submucosal glands of the ferret trachea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Slc26a9 is inhibited by the R-region of the cystic fibrosis transmembrane conductance regulator via the STAS domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

The solute carrier 26 family of proteins in epithelial ion transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

The interaction of pendrin and the epithelial sodium channel in blood pressure regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Submucosal glands and airway defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Regulation of fluid and electrolyte secretion in salivary gland acinar cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Liquid secretion properties of airway submucosal glands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

The SLC26 gene family of multifunctional anion exchangers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Regulation of intracellular pH in Calu-3 human airway cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Expression pattern of the mouse ortholog of the Pendred's syndrome gene (Pds) suggests a key role for pendrin in the inner ear

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

The Pendred syndrome gene encodes a chloride-iodide transport protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Evidence that Calu-3 human airway cells secrete bicarbonate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

10 September 2017

CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

Acid and base secretion in the Calu-3 model of human serous cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

Regulation of apical surface fluid and protein secretion in human airway epithelial cell line Calu-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

A "virtual gland" method for quantifying epithelial fluid secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

Gating of CFTR by the STAS domain of SLC26 transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

Activation of VPAC1 receptors by VIP and PACAP-27 in human bronchial epithelial cells induces CFTR-dependent chloride secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

14 September 2017

A(2) adenosine receptors regulate CFTR through PKA and PLA(2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

Functional and molecular characterization of an anion exchanger in airway serous epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

CFTR induces the expression of DRA along with Cl(-)/HCO(3)(-) exchange activity in tracheal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

Wound hypoxia and acidosis limit neutrophil bacterial killing mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

Intracellular pH modulates the generation of superoxide radicals by human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

25 September 2017

cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

17 June 2018

Chloride conductance of CFTR facilitates basal Cl-/HCO3- exchange in the villous epithelium of intact murine duodenum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

17 June 2018

Mucus secretion from single submucosal glands of pig. Stimulation by carbachol and vasoactive intestinal peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

17 June 2018

cAMP and genistein stimulate HCO3- conductance through CFTR in human airway epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

17 June 2018

Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

17 June 2018

A new role for bicarbonate secretion in cervico-uterine mucus release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Cl- is required for HCO3- entry necessary for sperm capacitation in guinea pig: involvement of a Cl-/HCO3- exchanger (SLC26A3) and CFTR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Functional characterization of wild-type and a mutated form of SLC26A4 identified in a patient with Pendred syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Chloride transport in microperfused interlobular ducts isolated from guinea-pig pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

HCO3- transport in a mathematical model of the pancreatic ductal epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3220502

21 August 2018

Influence of external pH on ciliary beat frequency in human bronchi and bronchioles

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of substance P-stimulated mucus secretion from porcine tracheal submucosal glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pH- and protein-dependent buffer capacity and viscosity of respiratory mucus. Their interrelationships and influence on health

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profound increase in viscosity and aggregation of pig gastric mucin at low pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Submucosal glands are the predominant site of CFTR expression in the human bronchus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CFTR involvement in chloride, bicarbonate, and liquid secretion by airway submucosal glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neglected ion: HCO3-

1 reference

https://pubmed.ncbi.nlm.nih.gov/21914796

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.266734

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 September 2017

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