(Q39249570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23125282%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans (English)

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17 February 2020

9

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17 February 2020

Tetsuya Terasaki

16

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17 February 2020

author name string

Yasuhiro Kazuki

1

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17 February 2020

Kaoru Kobayashi

2

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17 February 2020

Sasitorn Aueviriyavit

3

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17 February 2020

Takeshi Oshima

4

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17 February 2020

Yoshimi Kuroiwa

5

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17 February 2020

Yasuko Tsukazaki

6

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17 February 2020

Naoto Senda

7

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17 February 2020

Hiroki Kawakami

8

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17 February 2020

Satoshi Abe

10

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17 February 2020

Masato Takiguchi

11

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17 February 2020

Hidetoshi Hoshiya

12

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17 February 2020

Naoyo Kajitani

13

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17 February 2020

Shoko Takehara

14

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17 February 2020

Kinya Kubo

15

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17 February 2020

Kan Chiba

17

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17 February 2020

Kazuma Tomizuka

18

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17 February 2020

Mitsuo Oshimura

19

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17 February 2020

publication date

2 November 2012

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17 February 2020

published in

Human Molecular Genetics

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17 February 2020

volume

22

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17 February 2020

issue

3

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17 February 2020

page(s)

578-592

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Cytochrome P-450 3A4: regulation and role in drug metabolism

17 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Developmental expression of the major human hepatic CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Potential strategies for minimizing mechanism-based inhibition of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Pharmacokinetics in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Establishment of transgenic mice carrying human fetus-specific CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Transfer of human artificial chromosome vectors into stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Human artificial chromosomes for gene delivery and the development of animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Fetus-specific expression of a form of cytochrome P-450 in human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Transgenic mouse models of human CYP3A4 gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Species differences in mechanism-based inactivation of CYP3A in humans, rats and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Expression and regulation of human fetal-specific CYP3A7 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Potential role for human cytochrome P450 3A4 in estradiol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Identification of a novel polymorphic enhancer of the human CYP3A4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

MicroRNAs regulate CYP3A4 expression via direct and indirect targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Characterization of mouse small intestinal cytochrome P450 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468

Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS468