(Q39294625)

10 September 2017

title

Mammalian PER2 regulates AKT activation and DNA damage response (English)

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10 September 2017

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Xiaoming Yang

1

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10 September 2017

Xuezhong He

series ordinal

2

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10 September 2017

Zhengguan Yang

series ordinal

3

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10 September 2017

Esmaiel Jabbari

series ordinal

4

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10 September 2017

language of work or name

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21 August 2012

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Biochemistry and Cell Biology

10 September 2017

published in

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10 September 2017

volume

90

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10 September 2017

issue

6

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10 September 2017

page(s)

675-682

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Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock

10 September 2017

cites work

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

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AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition

21 January 2018

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Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.

21 January 2018

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The potential role of Akt phosphorylation in human cancers

21 January 2018

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The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

21 January 2018

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Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.

21 January 2018

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Per2 is a C/EBP target gene implicated in myeloid leukemia.

21 January 2018

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Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia

21 January 2018

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The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells

21 January 2018

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DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway.

21 January 2018

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Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence

21 January 2018

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Circadian gene mPer2 overexpression induces cancer cell apoptosis

21 January 2018

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Per3, a circadian gene, is required for Chk2 activation in human cells

21 January 2018

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Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

21 January 2018

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AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells

21 January 2018

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

21 January 2018

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Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

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Control mechanism of the circadian clock for timing of cell division in vivo

21 January 2018

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Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer.

21 January 2018

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AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.

21 January 2018

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Coordination of circadian timing in mammals

21 January 2018

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Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.

21 January 2018

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Expression of the circadian clock genes Per1 and Per2 in sporadic and familial breast tumors

21 January 2018

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Period 2 mutation accelerates ApcMin/+ tumorigenesis

21 January 2018

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Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.

21 January 2018

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Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm

21 January 2018

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Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O2012-025

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10 September 2017

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