(Q3931282)

English

Calcitonin receptor

mammalian protein found in Homo sapiens

calcitonin receptor
calcitonin receptors
Receptors, Calcitonin
CALCR

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30988

GPCR, family 2, calcitonin receptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30988

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcitonin binding

determination method

3 references

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Cloning and characterization of an abundant subtype of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

signal transducer activity

determination method

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

protein binding

determination method

2 references

transmembrane signaling receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amyloid-beta binding

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

calcitonin gene-related peptide receptor activity

determination method

1 reference

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amylin receptor activity

determination method

3 references

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

determination method

2 references

plasma membrane

determination method

2 references

integral component of plasma membrane

determination method

1 reference

8 April 2019

Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amylin receptor complex 1

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amylin receptor complex 2

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amylin receptor complex 3

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

biological process

positive regulation of adenylate cyclase activity

determination method

3 references

3 January 2017

Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

3 January 2017

Molecular characterization of two novel isoforms of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

3 January 2017

Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

3 January 2017

Cloning and characterization of an abundant subtype of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

receptor internalization

determination method

1 reference

3 January 2017

Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

response to glucocorticoid

determination method

1 reference

8 April 2019

Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

activation of phospholipase C activity

determination method

1 reference

3 January 2017

Hemolytic anemia associated with Wilson's disease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

activation of adenylate cyclase activity

determination method

1 reference

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

protein transport

determination method

1 reference

3 January 2017

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

protein localization to plasma membrane

determination method

1 reference

3 January 2017

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P30988

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

G protein-coupled receptor signaling pathway

determination method

3 references

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

5 references

8 April 2019

Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

8 April 2019

Molecular characterization of two novel isoforms of the human calcitonin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of protein kinase A signaling

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of cell death

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

cross-receptor inhibition within G protein-coupled receptor heterodimer

determination method

1 reference

8 April 2019

Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

amylin receptor signaling pathway

determination method

response to amyloid-beta

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

positive regulation of calcium ion import across plasma membrane

determination method

1 reference

8 April 2019

Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30988

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103758

salmon calcitonin

object has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201661

Gene Atlas image

PBB GE CALCR 207886 s at fs.png
732 × 530; 12 KB

0 references

GPCR, family 2, extracellular hormone receptor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30988

GPCR, family 2, secretin-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30988

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30988

Identifiers

MeSH descriptor ID

subject named as

Receptors, Calcitonin

0 references

D12.776.543.750.695.100

0 references

D12.776.543.750.750.200

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000413179

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000413179

ENSP00000391369

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391369

ENSP00000352561

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352561

ENSP00000353385

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353385

ENSP00000377959

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000377959

ENSP00000389295

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389295

ENSP00000497687

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497687

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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