(Q39328853)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

4

1 reference

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5 February 2020

Anna Dittrich

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Martin Mönnigmann

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Fred Schaper

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Tom Quaiser

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Christina Khouri

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

publication date

19 June 2012

1 reference

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5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

2119-2134

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

IL-6 signal transduction and its physiological roles: the signal orchestration model

5 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Chemical Dissection of the Effects of Tyrosine Phosphorylation of SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Control mechanism of JAK/STAT signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Theoretical analysis of time-to-peak responses in biological reaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Systematic identifiability testing for unambiguous mechanistic modeling--application to JAK-STAT, MAP kinase, and NF-kappaB signaling pathway models

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Cytoplasmic STAT proteins associate prior to activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

STATs dimerize in the absence of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

A simple work flow for biologically inspired model reduction--application to early JAK-STAT signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Structure-based kinetic models of modular signaling protein function: focus on Shp2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2MB05488D

21 January 2018

Identifiers

DOI

10.1039/C2MB05488D

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22711165%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference