(Q39338519)

11 September 2017

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title

Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation (English)

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11 September 2017

D R Sibley

1

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PubMed ID

2855789

11 September 2017

R J Lefkowitz

series ordinal

2

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11 September 2017

1 March 1987

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11 September 2017

Molecular Neurobiology

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11 September 2017

1

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11 September 2017

1-2

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11 September 2017

121-154

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https://scigraph.springernature.com/pub.10.1007/bf02935266

11 September 2017

0 references

cites work

Determination of the desensitization of β-adrenergic receptors by [3H]CGP-12177

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02935266

Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02935266

3HCGP-12177, A β-Adrenergic Ligand Suitable for Measuring Cell Surface Receptors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02935266

Adenylate cyclase from bovine brain cortex: purification and characterization of the catalytic unit

21 January 2018

1 reference

12 December 2020

Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni)

1 reference

12 December 2020

Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.

1 reference

12 December 2020

Agonist-induced desensitization of the beta-adrenergic receptor-linked adenylate cyclase.

1 reference

12 December 2020

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells

1 reference

12 December 2020

Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells

1 reference

12 December 2020

Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase

1 reference

12 December 2020

Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System

1 reference

12 December 2020

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments

1 reference

12 December 2020

Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors

1 reference

12 December 2020

Activation of adipocyte adenylate cyclase by protein kinase C.

1 reference

12 December 2020

Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: Degradation of the Mr = 49,000 protein explains apparent heterogeneity

1 reference

12 December 2020

Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin

1 reference

12 December 2020

Induction of refractoriness to isoproterenol by prior treatment of C6-2B rat astrocytoma cells with cholera toxin

1 reference

12 December 2020

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

1 reference

12 December 2020

Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system

1 reference

12 December 2020

Desensitization of enucleated cells to hormones and role of cytoskeleton in control of normal hormonal response

1 reference

12 December 2020

Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors.

1 reference

12 December 2020

Phorbol esters increase GTP-dependent adenylate cyclase activity in rat brain striatal membranes.

1 reference

12 December 2020

Beta-adrenergic regulation of Sertoli cell adenylyl cyclase: desensitization by homologous hormone

1 reference

12 December 2020

Functional alterations in components of pigeon erythrocyte adenylate cyclase following desensitization to isoproterenol

1 reference

12 December 2020

Agonist-induced changes in beta-adrenergic receptors on intact cells

1 reference

12 December 2020

Modulation of adenylate cyclase of human platelets by phorbol ester. Impairment of the hormone-sensitive inhibitory pathway

1 reference

12 December 2020

Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells

1 reference

12 December 2020

Comparison of binding of 125I-iodopindolol to control and desensitized cells at 37 degrees and on ice.

1 reference

12 December 2020

Hormone-Induced Homologous and Heterologous Desensitization in the Rat Adipocyte*

1 reference

12 December 2020

Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells

1 reference

12 December 2020

Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity

1 reference

12 December 2020

N6,O2'-Dibutyryl cyclic AMP and cholera toxin-induced beta-adrenergic receptor loss in cultured cells

1 reference

12 December 2020

Turnover of beta 1- and beta 2-adrenergic receptors after down-regulation or irreversible blockade.

1 reference

12 December 2020

A biochemical study of receptor internalization during beta-adrenergic receptor desensitization in frog erythrocytes

1 reference

12 December 2020

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulator

1 reference

12 December 2020

Interactions of full and partial agonists with beta-adrenergic receptors on intact L6 muscle cells

1 reference

12 December 2020

Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells

1 reference

12 December 2020

Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function

1 reference

12 December 2020

Activation, desensitization, and recycling of frog erythrocyte beta-adrenergic receptors. Differential perturbation by in situ trypsinization

1 reference

12 December 2020

Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor

1 reference

12 December 2020

A Hormone-independent Rise of Adenosine 3',5'-Monophosphate Desensitizes Coupling of beta-Adrenergic Receptors to Adenylate Cyclase in Rat Glioma C6-Cells

1 reference

12 December 2020

Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.

1 reference

12 December 2020

Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.

1 reference

12 December 2020

The protein kinase C activator phorbol-12-myristate-13-acetate enhances cyclic AMP accumulation in pheochromocytoma cells

1 reference

12 December 2020

Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex

1 reference

12 December 2020

Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells

1 reference

12 December 2020

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor

1 reference

12 December 2020

Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit

1 reference

12 December 2020

A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase

1 reference

12 December 2020

Functional Desensitisation of β-Adrenergic Receptors of Avian Erythrocytes by Catecholamines and Adenosine 3′,5′-Phosphate

1 reference

12 December 2020

Purification of the catalyst of adenylate cyclase.

1 reference

12 December 2020

Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase

1 reference

12 December 2020

Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells

1 reference

12 December 2020

Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors

1 reference

12 December 2020

Cyclic GMP cascade of vision

1 reference

12 December 2020

Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis

1 reference

12 December 2020

Phorbol ester inhibits myoblast fusion and activates beta-adrenergic receptor coupled adenylate cyclase

1 reference

12 December 2020

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor

1 reference

12 December 2020

Evidence for internalization of the recognition site of β-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol

1 reference

12 December 2020

Phosphorylation of frog photoreceptor membranes induced by light

1 reference

12 December 2020

Genetic analysis of beta-adrenergic receptor internalization and down-regulation

1 reference

12 December 2020

Receptor-mediated endocytosis of hormones in cultured cells

1 reference

12 December 2020

Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines

1 reference

12 December 2020

Signal transduction by guanine nucleotide binding proteins

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12 December 2020

Reversal of catecholamine refractoriness by inhibitors of RNA and protein synthesis.

1 reference

12 December 2020

Down-regulation of gonadotropin and beta-adrenergic receptors by hormones and cyclic AMP.

1 reference

12 December 2020

Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction

1 reference

12 December 2020

Carbachol induces desensitization of cardiac beta-adrenergic receptors through muscarinic M1 receptors

1 reference

12 December 2020

Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells

1 reference

12 December 2020

Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles

1 reference

12 December 2020

Phosphorylation of rhodopsin in bovine photoreceptor membranes. Dark reaction after illumination

1 reference

12 December 2020

The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1 reference

12 December 2020

Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor

1 reference

12 December 2020

Mammalian .beta.2-adrenergic receptor: purification and characterization

1 reference

12 December 2020

Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation

1 reference

12 December 2020

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites

1 reference

12 December 2020

Agonist-mediated regulation of alpha 1- and beta 2-adrenergic receptor metabolism in a muscle cell line, BC3H-1.

1 reference

12 December 2020

Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells

1 reference

12 December 2020

Involvement of cyclic amp and protein synthesis in catecholamine refractoriness

1 reference

12 December 2020

CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.

1 reference

12 December 2020

Potentiation of cholera toxin-stimulated cyclic AMP production in cultured cells by inhibitors of RNA and protein synthesis

1 reference

12 December 2020

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors

1 reference

12 December 2020

Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells

1 reference

12 December 2020

Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis

1 reference

12 December 2020

Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes

1 reference

12 December 2020

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1 reference

12 December 2020

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution

1 reference

12 December 2020

Catecholamine-Induced Alteration in Sedimentation Behavior of Membrane Bound β-Adrenergic Receptors

1 reference

12 December 2020

Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization

1 reference

12 December 2020

Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization

1 reference

12 December 2020

Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists

1 reference

12 December 2020

Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component

1 reference

12 December 2020

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro

1 reference

12 December 2020

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells

1 reference

12 December 2020

Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts. Role of regulatory components in desensitization.

1 reference

12 December 2020

Cytochalasin B enhances hormone and cholera toxin-stimulated cyclic AMP accumulation in S49 lymphoma cells

1 reference

12 December 2020

The fat cell beta-adrenergic receptor. Purification and characterization of a mammalian beta 1-adrenergic receptor

1 reference

12 December 2020

Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cells.

1 reference

12 December 2020

Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines

1 reference

12 December 2020

Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number

1 reference

12 December 2020

Functional integrity of desensitized beta-adrenergic receptors

1 reference

12 December 2020

Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors

1 reference

12 December 2020

Molecular Mechanisms of Coupling in Hormone Receptor‐Adenylate Cyclase Systems

1 reference

12 December 2020

Human Chorionic Gonadotropin-Induced Heterologous Desensitization of Adenylyl Cyclase from Highly Luteinized Rat Ovaries: Attenuation of Regulatory N Component Activity*

1 reference

12 December 2020

Agonist-induced changes in the properties of beta-adrenergic receptors on intact S49 lymphoma cells. Time-dependent changes in the affinity of the receptor for agonists

1 reference

12 December 2020

The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

12 December 2020

A family of receptors coupled to guanine nucleotide regulatory proteins

1 reference

12 December 2020

Angiotensin II and phorbol ester enhance isoproterenol- and vasoactive intestinal peptide (VIP)-induced cyclic AMP accumulation in vascular smooth muscle cells

1 reference

12 December 2020

Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization

1 reference

12 December 2020

Interactions of agonists and antagonists with beta-adrenergic receptors on intact L6 muscle cells

1 reference

12 December 2020

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes.

1 reference

12 December 2020

G proteins and dual control of adenylate cyclase

1 reference

12 December 2020

An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloroadenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations

1 reference

12 December 2020

Do agonists promote rapid internalization of beta-adrenergic receptors?

1 reference

12 December 2020

Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling

1 reference

12 December 2020

Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes

1 reference

12 December 2020

Involvement of microtubules in the isoproterenol-induced ‘down’-regulation of myocardial β-adrenergic receptors

1 reference

12 December 2020

Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis

1 reference

12 December 2020

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase

1 reference

12 December 2020

Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase

1 reference

12 December 2020

Association of sequestered beta-adrenergic receptors with the plasma membrane: A novel mechanism for receptor down regulation

1 reference

12 December 2020

Role of cyclic AMP in cardiac beta-adrenoceptor desensitization: studies using prenalterol and inhibitors of phosphodiesterase

1 reference

12 December 2020

Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism

1 reference

12 December 2020

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process

1 reference

12 December 2020

Protein Phosphorylation Catalyzed by Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases

1 reference

12 December 2020

Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist

1 reference

12 December 2020

Desensitization of the mammalian beta-adrenergic receptor: analysis of receptor redistribution on nonlinear sucrose gradients.

1 reference

12 December 2020

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes

1 reference

12 December 2020

High-affinity binding of agonists to beta-adrenergic receptors on intact cells

1 reference

12 December 2020

Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase

1 reference

12 December 2020

Amplification and adaptation in regulatory and sensory systems.

1 reference

12 December 2020

Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization

1 reference

12 December 2020

Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1 reference

12 December 2020

The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling

1 reference

12 December 2020

Evidence for the appearance of an uncoupled form of the beta-adrenergic receptor distinct from the internalized receptor.

1 reference

12 December 2020

Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization

1 reference

12 December 2020

Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: desensitization to catecholamines and prostaglandins

1 reference

12 December 2020

Message Transmission: Receptor Controlled Adenylate Cyclase System

1 reference

12 December 2020

The partial primary structure of bovine rhodopsin and its topography in the retinal rod cell disc membrane

1 reference

12 December 2020

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine

1 reference

12 December 2020

Specific muscarinic-cholinergic desensitization in the neuroblastoma-glioma hybrid NG108-15.

1 reference

12 December 2020

Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine

1 reference

12 December 2020

Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02935266

1 reference

11 September 2017

1 reference

PubMed ID

2855789