(Q39344938)

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BTG2 loss and miR-21 upregulation contribute to prostate cell transformation by inducing luminal markers expression and epithelial-mesenchymal transition.

scientific article published on 21 May 2012

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2 February 2020

BTG2 loss and miR-21 upregulation contribute to prostate cell transformation by inducing luminal markers expression and epithelial-mesenchymal transition (English)

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2 February 2020

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2 February 2020

Marcello Maugeri

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2 February 2020

Federica Francescangeli

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2 February 2020

Michelangelo Cordenonsi

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2 February 2020

Désirée Bonci

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2 February 2020

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V Coppola

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2 February 2020

M Patrizii

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2 February 2020

A Cannistraci

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A Addario

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S Piccolo

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L Memeo

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A Pagliuca

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G Muto

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2 February 2020

R De Maria

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2 February 2020

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21 May 2012

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2 February 2020

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2 February 2020

1843-1853

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2 February 2020

Cell differentiation lineage in the prostate

1 reference

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The proliferative function of basal cells in the normal and hyperplastic human prostate

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Stem cells in prostate and prostate cancer development

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p63 is a prostate basal cell marker and is required for prostate development

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21 January 2018

p63 regulates commitment to the prostate cell lineage

1 reference

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Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

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The basics of epithelial-mesenchymal transition

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Expression of B-cell translocation gene 2 protein in normal human tissues

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Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

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Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription

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TIS21 (/BTG2/PC3) as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule.

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A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation

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Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma

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Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein

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Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis

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MicroRNAs: genomics, biogenesis, mechanism, and function

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Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

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MicroRNA signatures in human cancers

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Oncomirs - microRNAs with a role in cancer

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A microRNA expression signature of human solid tumors defines cancer gene targets

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Improvement of prostate cancer detection by integrating the PSA test with miRNA expression profiling

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MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells

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miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

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Btg2 enhances retinoic acid-induced differentiation by modulating histone H4 methylation and acetylation

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Nuclear localization of Tob is important for regulation of its antiproliferative activity

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Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18.

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Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications Part 2. Tumorigenic cell lines

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p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.

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Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.

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OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.

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Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma

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The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

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Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells

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MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

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Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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Prostate cancer stem cells: do they have a basal or luminal phenotype?

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Stem/progenitor and intermediate cell types and the origin of human prostate cancer

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Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: a stem cell model

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BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity

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Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

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Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.

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Identifiers

10.1038/ONC.2012.194

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22614007%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22614007%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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