(Q39354618)

11 September 2017

title

Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress (English)

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human embryonic stem cell

11 September 2017

main subject

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Joëlle A Desmarais

1

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11 September 2017

Michele J Hoffmann

2

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11 September 2017

Gregg Bingham

3

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11 September 2017

Mary E Gagou

4

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11 September 2017

Mark Meuth

5

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11 September 2017

Peter W Andrews

6

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11 September 2017

publication date

1 July 2012

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11 September 2017

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11 September 2017

volume

30

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11 September 2017

issue

7

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11 September 2017

page(s)

1385-1393

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Stem cells from the Mammalian blastocyst

11 September 2017

cites work

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From teratocarcinomas to embryonic stem cells

21 January 2018

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The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation

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Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

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Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

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Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

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DNA damage responses in human induced pluripotent stem cells and embryonic stem cells

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Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

21 January 2018

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Embryonic stem cell lines derived from human blastocysts

21 January 2018

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A comparative study of eight cell lines derived from human testicular teratocarcinoma.

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Cell-surface antigens of a clonal human embryonal carcinoma cell line: morphological and antigenic differentiation in culture.

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Surface antigens of human embryonic stem cells: changes upon differentiation in culture

21 January 2018

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Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.

21 January 2018

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Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.

21 January 2018

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ATM is required for the cellular response to thymidine induced replication fork stress.

21 January 2018

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

21 January 2018

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

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Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

21 January 2018

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

21 January 2018

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The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

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Cleavage-mediated activation of Chk1 during apoptosis

21 January 2018

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Chk1 suppressed cell death

21 January 2018

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Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

21 January 2018

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

21 January 2018

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ATR: an essential regulator of genome integrity

21 January 2018

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Analysis of protein dynamics at active, stalled, and collapsed replication forks.

21 January 2018

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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

21 January 2018

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Pathways of mammalian replication fork restart.

21 January 2018

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Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells

21 January 2018

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

21 January 2018

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Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

21 January 2018

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Chk1 promotes replication fork progression by controlling replication initiation

21 January 2018

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Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells

21 January 2018

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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

21 January 2018

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Modeling the evolution of culture-adapted human embryonic stem cells.

21 January 2018

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Analysis of apoptosis in the preimplantation bovine embryo using TUNEL.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1117

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11 September 2017

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