(Q39372034)

11 September 2017

title

BLTK1 murine Leydig cells: a novel steroidogenic model for evaluating the effects of reproductive and developmental toxicants (English)

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11 September 2017

Agnes L Forgacs

1

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11 September 2017

Qi Ding

2

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11 September 2017

Rosemary G Jaremba

3

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11 September 2017

Ilpo T Huhtaniemi

4

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11 September 2017

Nafis A Rahman

5

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11 September 2017

Timothy R Zacharewski

6

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11 September 2017

publication date

29 March 2012

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11 September 2017

published in

Toxicological Sciences

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11 September 2017

volume

127

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11 September 2017

issue

2

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11 September 2017

page(s)

391-402

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The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on foetal male rat steroidogenesis

11 September 2017

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Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses.

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The costs of REACH. REACH is largely welcomed, but the requirement to test existing chemicals for adverse effects is not good news for all.

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Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells

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Desensitization to gonadotropins in cultured Leydig tumor cells involves loss of gonadotropin receptors and decreased capacity for steroidogenesis

21 January 2018

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Atrazine inhibition of testosterone production in rat males following peripubertal exposure

21 January 2018

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Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse

21 January 2018

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Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations

21 January 2018

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21 January 2018

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Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes

21 January 2018

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Recombinant forms of rat and human luteinizing hormone and follicle-stimulating hormone; comparison of functions in vitro and in vivo

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production

21 January 2018

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Assessment of chemical effects on aromatase activity using the H295R cell line

21 January 2018

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Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

21 January 2018

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The mouse inhibin alpha-subunit promoter directs SV40 T-antigen to Leydig cells in transgenic mice

21 January 2018

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A New Frontier in Understanding the Mechanisms of Developmental Abnormalities

21 January 2018

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Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals

21 January 2018

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Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action

21 January 2018

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Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan

21 January 2018

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Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells

21 January 2018

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Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test.

21 January 2018

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Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in zebrafish: general and reproductive toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Direct and indirect impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on adult mouse Leydig cells: an in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

A biphasic effect of the fungicide prochloraz on aldosterone, but not cortisol, secretion in human adrenal H295R cells--underlying mechanisms

21 January 2018

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The foetal Leydig cell-- differentiation, function and regulation

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Mouse Leydig tumor cells produce C-19 steroids, including testosterone

21 January 2018

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Regulation of expression of steroidogenic enzymes in Leydig cells

21 January 2018

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Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine.

21 January 2018

1 reference

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21 January 2018

Testicular cell lines

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Establishment of gonadotropin-responsive murine leydig tumor cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Atrazine is a competitive inhibitor of phosphodiesterase but does not affect the estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Arachidonic acid release from rat Leydig cells: the involvement of G protein, phospholipase A2 and regulation of cAMP production

21 January 2018

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The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals.

21 January 2018

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The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants

21 January 2018

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Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds

21 January 2018

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Pathways of endocrine disruption during male sexual differentiation and masculinization

21 January 2018

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Presence of Identical Mitochondrial Proteins in Unstimulated Constitutive Steroid-Producing R2C Rat Leydig Tumor and Stimulated Nonconstitutive Steroid-Producing MA-10 Mouse Leydig Tumor Cells*

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Changes in testicular morphology and steroidogenesis in adult rats exposed to Atrazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Prochloraz: an imidazole fungicide with multiple mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Cyclic AMP and arachidonic acid: a tale of two pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Endocrine-disrupting chemicals as modulators of sex steroid synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Effect of two major N-nitroso hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on earthworm reproductive success.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

Effects of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) metabolites on cricket (Acheta domesticus) survival and reproductive success

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

The effects of triclosan on puberty and thyroid hormones in male Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS121

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFS121

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11 September 2017

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