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Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.
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Europe PubMed Central
PMC publication ID
2831321
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
title
Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
author
Theodoros Kantidakis
series ordinal
1
1 reference
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Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
Theodoros Kantidakis
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2
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stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
author name string
Robert J White
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3
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Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
language of work or name
English
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publication date
3 December 2009
1 reference
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Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
published in
Nucleic Acids Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
volume
38
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
page(s)
1228-1239
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Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
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PubMed Central
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Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome
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Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation
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CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription
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The initiator core promoter element antagonizes repression of TATA-directed transcription by negative cofactor NC2
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A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC
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Human La is found at RNA polymerase III-transcribed genes in vivo
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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
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TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo
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The NC2 alpha and beta subunits play different roles in vivo
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PubMed Central
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11 September 2017
Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae
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PubMed Central
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11 September 2017
Recruitment of RNA polymerase III to its target promoters
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP)
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PubMed Central
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11 September 2017
A system for stable expression of short interfering RNAs in mammalian cells
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11 September 2017
Association of human TFIID-promoter complexes with silenced mitotic chromatin in vivo
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11 September 2017
Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.
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PubMed Central
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11 September 2017
Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo
1 reference
stated in
PubMed Central
reference URL
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11 September 2017
Activation of RNA polymerase III transcription in cells transformed by simian virus 40
1 reference
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PubMed Central
reference URL
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11 September 2017
Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2alpha homolog that has both positive and negative roles in transcription in vivo
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PubMed Central
reference URL
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11 September 2017
Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
Functional dissection of a human Dr1-DRAP1 repressor complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
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11 September 2017
Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
11 September 2017
Requirement of a corepressor for Dr1-mediated repression of transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
11 September 2017
Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
11 September 2017
Structure-function analysis of the TBP-binding protein Dr1 reveals a mechanism for repression of class II gene transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
11 September 2017
Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
11 September 2017
TFIIB recognition elements control the TFIIA-NC2 axis in transcriptional regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
14 September 2017
Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
14 September 2017
Direct activation of RNA polymerase III transcription by c-Myc
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
14 September 2017
Mitotic regulation of a TATA-binding-protein-containing complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
14 September 2017
Specific transcription from the adenovirus E2E promoter by RNA polymerase III requires a subpopulation of TFIID
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
14 September 2017
Multiple mechanisms contribute to the activation of RNA polymerase III transcription in cells transformed by papovaviruses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
17 June 2018
p53 is a general repressor of RNA polymerase III transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
17 June 2018
Differential regulation of RNA polymerases I, II, and III by the TBP-binding repressor Dr1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
17 June 2018
Family of proteins that interact with TFIID and regulate promoter activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
17 June 2018
Cell biology. RNA metabolism and oncogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
21 August 2018
Regulation of RNA polymerase III transcription by Maf1 in mammalian cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
21 August 2018
NC2 mobilizes TBP on core promoter TATA boxes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
21 August 2018
A basal transcription factor that activates or represses transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
21 August 2018
Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2831321
retrieved
2 December 2018
Non-coding RNA production by RNA polymerase III is implicated in cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19965767
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/NAR/GKP1102
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PMC publication ID
2831321
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
PubMed publication ID
19965767
1 reference
stated in
Europe PubMed Central
PMC publication ID
2831321
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
13 February 2020
ResearchGate publication ID
40452736
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