(Q39380065)

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Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.

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25 January 2020

Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice (English)

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25 January 2020

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based on heuristic

inferred from title

tumor progression

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based on heuristic

inferred from title

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25 January 2020

Christopher Dunham

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25 January 2020

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Cathy Lee

1

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25 January 2020

Abbas Fotovati

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25 January 2020

Joanna Triscott

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25 January 2020

James Chen

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25 January 2020

Chitra Venugopal

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25 January 2020

John M Kerr

8

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25 January 2020

Maite Verreault

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25 January 2020

Stephen Yip

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25 January 2020

Hiroaki Wakimoto

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25 January 2020

Chris Jones

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25 January 2020

Aarthi Jayanthan

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25 January 2020

Aru Narendran

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25 January 2020

Sheila K Singh

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25 January 2020

Sandra E Dunn

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25 January 2020

publication date

1 June 2012

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25 January 2020

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25 January 2020

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25 January 2020

6

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25 January 2020

1064-1075

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25 January 2020

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia

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Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

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Chemotherapy resistance of glioblastoma stem cells

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Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

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Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase

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YB-1 bridges neural stem cells and brain tumor-initiating cells via its roles in differentiation and cell growth

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Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas

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21 January 2018

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

1 reference

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21 January 2018

Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases

1 reference

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Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation

1 reference

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21 January 2018

Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

1 reference

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21 January 2018

The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.

1 reference

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21 January 2018

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

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21 January 2018

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

A role for Plk1 phosphorylation of NudC in cytokinesis

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

1 reference

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21 January 2018

Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA

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Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors

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21 January 2018

Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

21 January 2018

Normal cells, but not cancer cells, survive severe Plk1 depletion

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.1081

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Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells.

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Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

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Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

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Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

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Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

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Challenges in projecting clustering results across gene expression-profiling datasets

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Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors

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Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR

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Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

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Culture and isolation of brain tumor initiating cells.

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