(Q39381110)

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Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells.

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25 January 2020

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22410783%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Jessica Pickles

3

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25 January 2020

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H Yasaei

1

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25 January 2020

E Gilham

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25 January 2020

T P Roberts

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25 January 2020

M O'Donovan

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25 January 2020

R F Newbold

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25 January 2020

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12 March 2012

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25 January 2020

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25 January 2020

32

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25 January 2020

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25 January 2020

171-179

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25 January 2020

Impact of cellular senescence signature on ageing research

1 reference

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A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization

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Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence

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p53 and Ha-ras mutations in chemically induced hamster buccal pouch carcinomas.

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P53 expression, p53 and Ha-ras mutation and telomerase activation during nitrosamine-mediated hamster pouch carcinogenesis.

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K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors

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The cDNA cloning and immunological characterization of hamster p53.

1 reference

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Localization of the Tp53 gene on Syrian hamster chromosome 9 by fluorescence in situ hybridization

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Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

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Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors

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Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors

1 reference

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21 January 2018

Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells.

1 reference

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21 January 2018

Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.

1 reference

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Cloning of the hamster p16 gene 5' upstream region and its aberrant methylation patterns in pancreatic cancer.

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Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.

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Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells

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Cellular senescence: mitotic clock or culture shock?

1 reference

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Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks.

1 reference

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Signatures of mutation and selection in the cancer genome

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Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.

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Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells

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Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells

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p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

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p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a

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The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)

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