(Q39383867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Translation initiation factor eIF4E is a target for tumor cell radiosensitization (English)

1 reference

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25 January 2020

1

1 reference

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25 January 2020

author name string

Eli S Williams

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Muhammad Jamal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Uma T Shankavaram

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Kevin Camphausen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

Philip J Tofilon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

language of work or name

English

0 references

publication date

7 March 2012

1 reference

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25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

volume

72

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

page(s)

2362-2372

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

eIF4E expression in tumors: its possible role in progression of malignancies

25 January 2020

cites work

1 reference

12 December 2020

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage

1 reference

12 December 2020

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

1 reference

12 December 2020

Expression of eukaryotic initiation factor 4E in gastric adenocarcinoma and its association with clinical outcome.

1 reference

12 December 2020

eIF4E--from translation to transformation

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12 December 2020

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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12 December 2020

Upstream and downstream of mTOR

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12 December 2020

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

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12 December 2020

Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes.

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12 December 2020

eIF4E is a central node of an RNA regulon that governs cellular proliferation

1 reference

12 December 2020

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

1 reference

12 December 2020

Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors

1 reference

12 December 2020

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

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12 December 2020

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

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12 December 2020

Targeting the eukaryotic translation initiation factor 4E for cancer therapy

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12 December 2020

Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

1 reference

12 December 2020

Radiation-induced gene translation profiles reveal tumor type and cancer-specific components

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12 December 2020

Ribavirin targets eIF4E dependent Akt survival signaling

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12 December 2020

1 reference

12 December 2020

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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12 December 2020

eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

1 reference

12 December 2020

Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin.

1 reference

12 December 2020

Regulation of protein synthesis by ionizing radiation.

1 reference

12 December 2020

Dissecting the role of mTOR: lessons from mTOR inhibitors

1 reference

12 December 2020

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

1 reference

12 December 2020

gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

1 reference

12 December 2020

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

1 reference

12 December 2020

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

1 reference

12 December 2020

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

1 reference

12 December 2020

Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer

1 reference

12 December 2020

Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.

1 reference

12 December 2020

Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer

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12 December 2020

Formation of the eIF4F translation-initiation complex determines sensitivity to anticancer drugs targeting the EGFR and HER2 receptors.

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12 December 2020

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair.

1 reference

12 December 2020

Oncogenic AKTivation of translation as a therapeutic target

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12 December 2020

A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer

1 reference

12 December 2020

The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination

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12 December 2020

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

12 December 2020

10.1158/0008-5472.CAN-12-0329

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

22397984

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22397984%20AND%20SRC:MED&resulttype=core&format=json