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Inhibition of Drp1 provides neuroprotection in vitro and in vivo.
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PMC publication ID
3422469
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
title
Inhibition of Drp1 provides neuroprotection in vitro and in vivo
(English)
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PMC publication ID
3422469
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24 January 2020
author
Carsten Culmsee
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8
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Europe PubMed Central
PMC publication ID
3422469
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24 January 2020
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J Grohm
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3422469
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
S-W Kim
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24 January 2020
U Mamrak
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3
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24 January 2020
S Tobaben
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4
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3422469
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24 January 2020
A Cassidy-Stone
series ordinal
5
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3422469
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
J Nunnari
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6
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24 January 2020
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7
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24 January 2020
publication date
2 March 2012
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3422469
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24 January 2020
published in
Cell Death & Differentiation
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3422469
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24 January 2020
volume
19
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3422469
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24 January 2020
issue
9
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retrieved
24 January 2020
page(s)
1446-1458
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PMC publication ID
3422469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
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24 January 2020
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3422469/fullTextXML
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A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina
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Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
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Mitochondrial outer membrane permeabilization during apoptosis: the role of mitochondrial fission
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11 September 2017
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases
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11 September 2017
Mitochondrial fusion and fission in cell life and death
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11 September 2017
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
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11 September 2017
Bid stands at the crossroad of stress-response pathways
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Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia
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11 September 2017
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.
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PubMed Central
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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
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11 September 2017
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
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11 September 2017
Mitochondrial fragmentation in neurodegeneration
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11 September 2017
Bid-induced release of AIF from mitochondria causes immediate neuronal cell death
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11 September 2017
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
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11 September 2017
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
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11 September 2017
Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons
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11 September 2017
Targeting Bid to prevent programmed cell death in neurons.
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Role of Bax and Bak in mitochondrial morphogenesis
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Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.
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11 September 2017
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11 September 2017
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
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11 September 2017
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
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11 September 2017
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
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11 September 2017
Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons
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14 September 2017
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury
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14 September 2017
Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death.
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14 September 2017
Mitochondrial bioenergetics and structural network organization
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14 September 2017
Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum
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14 September 2017
Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.
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14 September 2017
Cellular mechanisms of resistance to chronic oxidative stress
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25 September 2017
Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
Mitochondrial fusion protects against neurodegeneration in the cerebellum.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
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21 August 2018
Combination therapy in ischemic stroke: synergistic neuroprotective effects of memantine and clenbuterol.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
retrieved
21 August 2018
Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422469
retrieved
21 August 2018
Identifiers
DOI
10.1038/CDD.2012.18
1 reference
stated in
Europe PubMed Central
PMC publication ID
3422469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PMC publication ID
3422469
1 reference
stated in
Europe PubMed Central
PMC publication ID
3422469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
PubMed publication ID
22388349
1 reference
stated in
Europe PubMed Central
PMC publication ID
3422469
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22388349%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 January 2020
ResearchGate publication ID
221886291
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