(Q39386920)

11 September 2017

The use of clinical trial simulation to support dose selection: application to development of a new treatment for chronic neuropathic pain (English)

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11 September 2017

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chronic neuropathic pain

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author name string

Peter A Lockwood

1

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11 September 2017

Jack A Cook

2

1 reference

11 September 2017

Wayne E Ewy

3

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11 September 2017

Jaap W Mandema

4

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11 September 2017

language of work or name

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1 November 2003

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11 September 2017

Pharmaceutical Research

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11 September 2017

20

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11 September 2017

1752-1759

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11 September 2017

11

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Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models

11 September 2017

1 reference

12 December 2020

Changes in prescribed drug doses after market introduction

1 reference

12 December 2020

Postmarketing drug dosage changes of 499 FDA-approved new molecular entities, 1980-1999.

1 reference

12 December 2020

Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial.

1 reference

12 December 2020

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1 reference

12 December 2020

Standardization of the rat paw formalin test for the evaluation of analgesics

1 reference

12 December 2020

A method for measurement of analgesic activity on inflamed tissue

1 reference

12 December 2020

Pharmacokinetics of gabapentin in subjects with various degrees of renal function

1 reference

12 December 2020

A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

1 reference

12 December 2020

Simulation of clinical trials

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12 December 2020

Characterization of a rat model of incisional pain.

1 reference

12 December 2020

Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat

1 reference

12 December 2020

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1 reference

12 December 2020

Validity of creatinine clearance estimates in the assessment of renal function.

1 reference

12 December 2020

Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale

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12 December 2020

Clinical trial simulation in drug development

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12 December 2020

10.1023/B:PHAM.0000003371.32474.EE

Identifiers

DOI

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11 September 2017

1 reference