(Q39392644)

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p38αMAPK interacts with and inhibits RARα: suppression of the kinase enhances the therapeutic activity of retinoids in acute myeloid leukemia cells.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22354283%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

p38αMAPK interacts with and inhibits RARα: suppression of the kinase enhances the therapeutic activity of retinoids in acute myeloid leukemia cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22354283%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

acute myeloid leukemia

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2

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23 January 2020

Gabriela Paroni

8

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23 January 2020

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M Gianni

1

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23 January 2020

N Bruck

3

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23 January 2020

A Rambaldi

4

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23 January 2020

G Borleri

5

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23 January 2020

M Terao

6

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23 January 2020

M Kurosaki

7

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23 January 2020

C Rochette-Egly

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23 January 2020

E Garattini

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23 January 2020

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22 February 2012

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23 January 2020

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23 January 2020

26

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23 January 2020

8

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23 January 2020

1850-1861

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23 January 2020

Improved outcome of acute promyelocytic leukemia with high WBC counts over the last 15 years: the European APL Group experience.

1 reference

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21 January 2018

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

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Modern approaches to treating acute promyelocytic leukemia

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All-trans retinoic acid and anthracycline monochemotherapy for the treatment of elderly patients with acute promyelocytic leukemia

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Acute promyelocytic leukemia as a paradigm for targeted therapy

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Acute promyelocytic leukemia: evolving therapeutic strategies

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Revisiting the differentiation paradigm in acute promyelocytic leukemia

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

1 reference

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Retinoids as differentiating agents in oncology: a network of interactions with intracellular pathways as the basis for rational therapeutic combinations

1 reference

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Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents

1 reference

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21 January 2018

New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation

1 reference

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21 January 2018

Vinexinß, an atypical "sensor" of retinoic acid receptor gamma signaling: union and sequestration, separation, and phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha

1 reference

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21 January 2018

Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARalpha and PML-RARalpha

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21 January 2018

Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells

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21 January 2018

Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis

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Molecular mechanisms behind the dose-dependent differential activation of MAPK pathways induced by transforming growth factor-beta1 in hematopoietic cells.

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Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte

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Determinants that control the specific interactions between TAB1 and p38alpha

1 reference

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Characterization of differentiation-inducer-resistant HL-60 cells.

1 reference

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Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin

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https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Immunodetection of multiple species of retinoic acid receptor alpha: evidence for phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Retinoid-dependent growth inhibition, differentiation and apoptosis in acute promyelocytic leukemia cells. Expression and activation of caspases

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

Acute promyelocytic leukaemia cells resistant to retinoic acid show further perturbation of the RAR alpha signal transduction system.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

21 January 2018

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

1 reference

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Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells

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Gene expression regulation by retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

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Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.50

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Tissue-transglutaminase contributes to neutrophil granulocyte differentiation and functions

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Tissue transglutaminase contributes to the all-trans-retinoic acid–induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia

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Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

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Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1.

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Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

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Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways.

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based on heuristic

inferred from DOI database lookup

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