(Q39398108)

11 September 2017

Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair (English)

1 reference

11 September 2017

Meghan J McFadden

1

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11 September 2017

Wilson K Y Lee

series ordinal

2

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11 September 2017

John D Brennan

series ordinal

3

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11 September 2017

Murray S Junop

series ordinal

4

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11 September 2017

language of work or name

English

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publication date

20 September 2013

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11 September 2017

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11 September 2017

82

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11 September 2017

2

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11 September 2017

187-194

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Targeting DNA repair mechanisms in cancer

11 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA repair dysregulation from cancer driver to therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA repair and resistance of gliomas to chemotherapy and radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Targeting DNA repair pathways: a novel approach to reduce cancer therapeutic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA repair pathways as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA repair inhibition: a selective tumour targeting strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Targeting the DNA damage response in oncology: past, present and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Synthetic lethality: exploiting the addiction of cancer to DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Homologous recombination and prostate cancer: a model for novel DNA repair targets and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Crystal structure of an Xrcc4-DNA ligase IV complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROT.24349

21 January 2018

Identifiers

DOI

10.1002/PROT.24349

1 reference

11 September 2017

1 reference