(Q39399152)

English

A novel pyrrolo[3, 2-d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet-derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis.

scientific article published on 15 March 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

A novel pyrrolo[3, 2-d]pyrimidine derivative, as a vascular endothelial growth factor receptor and platelet-derived growth factor receptor tyrosine kinase inhibitor, shows potent antitumor activity by suppression of tumor angiogenesis (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

0 references

tumor angiogenesis

1 reference

based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Yoshiko Awazu

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Akio Mizutani

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Yoshinori Nagase

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Yuya Oguro

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Hiroshi Miki

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Shinichi Imamura

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Akira Hori

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

publication date

15 March 2012

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

103

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

939-944

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Tumor angiogenesis: therapeutic implications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Sorafenib in advanced clear-cell renal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Sorafenib in advanced hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Roles of PDGF in animal development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Insight into the physiological functions of PDGF through genetic studies in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Targeting lymphangiogenesis to prevent tumour metastasis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

High interstitial fluid pressure - an obstacle in cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2012.02238.X

21 January 2018

Determinants of tumor blood flow: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22320850

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1349-7006.2012.02238.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22320850%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

ResearchGate publication ID

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