(Q39418451)

11 September 2017

The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus (English)

1 reference

11 September 2017

Michelle Craig Barton

9

1 reference

11 September 2017

Jiang Qian

1

1 reference

11 September 2017

Amod A Sarnaik

2

1 reference

11 September 2017

Tera M Bonney

3

1 reference

11 September 2017

Jeremy Keirsey

4

1 reference

11 September 2017

Kelly A Combs

5

1 reference

11 September 2017

Kira Steigerwald

6

1 reference

11 September 2017

Samir Acharya

7

1 reference

11 September 2017

Gregory K Behbehani

8

1 reference

11 September 2017

Andrew M Lowy

10

1 reference

11 September 2017

Joanna Groden

11

1 reference

11 September 2017

language of work or name

English

0 references

publication date

4 April 2008

1 reference

11 September 2017

1 reference

11 September 2017

135

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11 September 2017

1

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11 September 2017

152-162

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describes a project that uses

11 September 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2832605/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Biology of the adenomatous polyposis coli tumor suppressor

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Identification of c-MYC as a target of the APC pathway

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Geminin, an inhibitor of DNA replication, is degraded during mitosis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Lessons from hereditary colorectal cancer

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

APC binds to the novel protein EB1

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

'SPKK' motifs prefer to bind to DNA at A/T-rich sites

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

SPKK, a new nucleic acid-binding unit of protein found in histone

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Isoforms of the APC tumor suppressor and their ability to inhibit cell growth and tumorigenicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Egg extracts for nuclear import and nuclear assembly reactions.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Human protein tau represses DNA replication in vitro.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC tumour suppressor has a nuclear export function.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

The APC protein binds to A/T rich DNA sequences

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

In vitro reconstitution of nuclei for replication and transcription.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Role for a Xenopus Orc2-related protein in controlling DNA replication

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2832605

Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18474248

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear reconstitution in vitro: stages of assembly around protein-free DNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18474248

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1053/J.GASTRO.2008.03.074

1 reference

11 September 2017

1 reference

11 September 2017

PubMed publication ID

18474248

1 reference