(Q39446101)

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Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB. (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

apoptotic process

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1 reference

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inferred from title

author name string

J Gil

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

J Alcamí

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

M Esteban

3

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

language of work or name

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publication date

1 July 1999

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

PMC publication ID

12 September 2017

19

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

4653-4663

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

1 reference

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How cells respond to interferons

1 reference

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

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A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes

1 reference

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Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis

1 reference

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Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1 reference

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A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system

1 reference

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IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

1 reference

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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1 reference

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Dengue virus replication in human hepatoma cells activates NF-kappaB which in turn induces apoptotic cell death

1 reference

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Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

1 reference

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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

1 reference

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

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The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

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When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

1 reference

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Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.

1 reference

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1 reference

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NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress

1 reference

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Function and activation of NF-kappa B in the immune system

1 reference

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A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

1 reference

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Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.

1 reference

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12 September 2017

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84263

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Human Fas ligand: gene structure, chromosomal location and species specificity

1 reference

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Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.

1 reference

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Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes

1 reference

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Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1 reference

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The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2

1 reference

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Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases

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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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Inducible gene expression from vaccinia virus vectors

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Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1 reference

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

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Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection.

1 reference

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Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis

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PKR: a new name and new roles.

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1 reference

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

1 reference

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Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.

1 reference

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Life, death, and the pursuit of apoptosis.

1 reference

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DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

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21 August 2018

Even viruses can learn to cope with stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

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The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10373514

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.19.7.4653

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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