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An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes.
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Europe PubMed Central
PMC publication ID
84752
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
title
An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes
(English)
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Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
author
Andrei Okorokov
series ordinal
1
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Europe PubMed Central
PMC publication ID
84752
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
author name string
J Milner
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2
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Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
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1 November 2019
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English
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publication date
1 November 1999
1 reference
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Europe PubMed Central
PMC publication ID
84752
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
published in
Molecular and Cellular Biology
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
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1 November 2019
volume
19
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
issue
11
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
page(s)
7501-7510
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
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An ATP-ADP switch in MuB controls progression of the Mu transposition pathway
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Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
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12 September 2017
The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
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G protein mechanisms: insights from structural analysis
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12 September 2017
Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element
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PubMed Central
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12 September 2017
p53, the cellular gatekeeper for growth and division
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12 September 2017
Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40 kDa and 35 kDa fragments competent for sequence-specific DNA binding
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12 September 2017
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
p53: puzzle and paradigm
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PubMed Central
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12 September 2017
Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP
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PubMed Central
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12 September 2017
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways
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PubMed Central
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12 September 2017
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
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12 September 2017
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Refined solution structure of the oligomerization domain of the tumour suppressor p53
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Solution structure of the tetrameric minimum transforming domain of p53
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
p53 modulation of TFIIH-associated nucleotide excision repair activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
Electron-paramagnetic-resonance studies of manganese(II) complexes with elongation factor Tu from Bacillus stearothermophilus. Observation of a GTP hydrolysis intermediate state complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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12 September 2017
p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
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PubMed Central
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14 September 2017
A transcriptionally active DNA-binding site for human p53 protein complexes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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14 September 2017
Signalling to p53: where does it all start?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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25 September 2017
p53 in growth control and neoplasia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
25 September 2017
Molecular matchmakers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
25 September 2017
p53-catalyzed annealing of complementary single-stranded nucleic acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
25 September 2017
Wildtype p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
25 September 2017
How p53 binds DNA as a tetramer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
17 June 2018
Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
17 June 2018
Specific p53-DNA complexes contain an mdm2-related protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
17 June 2018
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
17 June 2018
Tumor suppressor p53: analysis of wild-type and mutant p53 complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
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17 June 2018
Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
17 June 2018
Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
21 August 2018
Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
21 August 2018
Mismatch repair, molecular switches, and signal transduction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
21 August 2018
p53 domains: identification and characterization of two autonomous DNA-binding regions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84752
retrieved
21 August 2018
[The human adenosine deaminase gene contains a p53-responsive element]
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10523638
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The oligomerization domain of p53: Crystal structure of the trigonal form
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10523638
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human p53 binds Holliday junctions strongly and facilitates their cleavage
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10523638
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Yeast and mammalian ras proteins have conserved biochemical properties
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10523638
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/10523638
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.19.11.7501
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
PMC publication ID
84752
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
PubMed publication ID
10523638
1 reference
stated in
Europe PubMed Central
PMC publication ID
84752
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523638%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 November 2019
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