(Q39457251)

English

Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury

scientific article published on January 2001

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scholarly article

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Europe PubMed Central

PMC publication ID

12 September 2017

Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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Gennaro Ciliberto

4

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

author name string

J I Leu

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

M A Crissey

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

J P Leu

3

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

R Taub

5

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Europe PubMed Central

PMC publication ID

12 September 2017

language of work or name

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publication date

1 January 2001

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Europe PubMed Central

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12 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

PMC publication ID

12 September 2017

21

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Europe PubMed Central

PMC publication ID

12 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

414-424

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Regulation of glucose production by the liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Transcriptional regulatory signals define cytokine-dependent and -independent pathways in liver regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Nuclear fusion of signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Mitogenic up-regulation of the PRL-1 protein-tyrosine phosphatase gene by Egr-1. Egr-1 activation is an early event in liver regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Liver regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Analysis of the distribution of binding sites for a tissue-specific transcription factor in the vertebrate genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Liver-specific expression of human insulin-like growth factor binding protein 1: functional role of transcription factor HNF1 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Characterization of the IL-6 Responsive Elements in the γ Fibrinogen Gene Promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Characterization of the 5'-flanking region of the gene for the alpha chain of human fibrinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Characterization of the 5'-flanking region for the human fibrinogen beta gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Liver cell specific gene transcription in vitro: the promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Immediate-early gene expression differs between regenerating liver, insulin-stimulated H-35 cells, and mitogen-stimulated Balb/c 3T3 cells. Liver-specific induction patterns of gene 33, phosphoenolpyruvate carboxykinase, and the jun, fos, and egr fa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

HNF1, a homeoprotein member of the hepatic transcription regulatory network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

12 September 2017

Differential role of hepatocyte nuclear factor-1 in the regulation of glucose-6-phosphatase catalytic subunit gene transcription by cAMP in liver- and kidney-derived cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Regulation of Smad7 promoter by direct association with Smad3 and Smad4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Liver regeneration 4: transcriptional control of liver regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Liver-enriched transcription factors and hepatocyte differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Liver regeneration in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Two distinct factors interact with the promoter regions of several liver-specific genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Versatile molecular glue. Transcriptional control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Detection of a novel transcription factor for the A alpha fibrinogen gene in response to interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Characterization of the 5'-flanking region of the gene for the gamma chain of human fibrinogen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

25 September 2017

Insulin-like growth factor binding protein-1: recent findings and new directions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

Interplay of the Liver-Enriched trans-Acting Factors, DBP and HNF1, in the Transactivation of Human IGFBP-1 Promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

HNF1 Activates Transcription of the Human Gene for Insulin-Like Growth Factor Binding Protein-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

Structure and localization of the IGFBP-1 gene and its expression during liver regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

Human beta-fibrinogen gene expression. Upstream sequences involved in its tissue specific expression and its dexamethasone and interleukin 6 stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

17 June 2018

Liver-specific and proliferation-induced deoxyribonuclease I hypersensitive sites in the mouse insulin-like growth factor binding protein-1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

21 August 2018

Cytokines and the hepatic acute phase response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86585

21 August 2018

Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cis-acting promoter elements in tissue-specific albumin gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A growing coactivator network

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte nuclear factor 1alpha is an accessory factor required for activation of glucose-6-phosphatase gene transcription by glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/11134330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.21.2.414-424.2001

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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