(Q39464319)

12 September 2017

1 reference

title

Pharmacology and structure-activity relationships of alpha 2-adrenoceptor antagonists (English)

1 reference

12 September 2017

1 reference

Clark RD

1

1 reference

12 September 2017

Michel AD

series ordinal

2

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12 September 2017

Whiting RL

series ordinal

3

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12 September 2017

publication date

1 January 1986

1 reference

Progress in medicinal chemistry

12 September 2017

published in

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12 September 2017

volume

23

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12 September 2017

page(s)

1-39

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A study of the adrenotropic receptors

12 September 2017

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Alpha-Adrenergic Receptor Subtypes

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Receptors under pressure. An update on baroreceptors

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7 January 2021

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7 January 2021

Release of noradrenaline and dopamine by nerve stimulation in the cat spleen perfused with 3H‐dopamine

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7 January 2021

Influence of ?-receptor stimulants on noradrenaline release

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7 January 2021

A further attempt to characterize sedative receptors activated by clonidine in chickens and mice

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7 January 2021

Presynaptic regulation of catecholamine release

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7 January 2021

Novel α2-adrenoreceptors primarily responsible for inducing human platelet aggregation

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7 January 2021

Evidence for the α2 nature of the α-adrenergic receptor inhibiting lipolysis in human fat cells

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7 January 2021

Evidence for two distinct types of postsynaptic alpha-adrenoceptor in vascular smooth muscle in vivo

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7 January 2021

A functional basis for classification of α-adrenergic receptors

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7 January 2021

Investigation into different types of post- and presynaptic α-adrenoceptors at cardiovascular sites in rats

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7 January 2021

Presynaptic activity of the imidazolidine derivative ST 587, a highly selective alpha 1-adrenoceptor agonist

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7 January 2021

An examination of age-related changes in pre- and postsynaptic α-adrenoceptors in the rat isolated vas deferens

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7 January 2021

Role of phosphatidylinositol turnover in alpha 1 and of adenylate cyclase inhibition in alpha 2 effects of catecholamines.

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7 January 2021

Pharmacological characterisation of the presynaptic α-adrenoceptor in the rat vas deferens

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7 January 2021

Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum

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7 January 2021

An electropharmacological analyses of the effects of some drugs on neuromuscular transmission in the vas deferens of the guinea-pig

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7 January 2021

Possible subdivision of postsynaptic α-adrenoceptors mediating pressor responses in the pithed rat

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7 January 2021

α2-Adrenoceptor agonists induce mydriasis in the rat by an action within the central nervous system

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7 January 2021

Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors

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7 January 2021

Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta

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7 January 2021

Effect of duration and frequency of stimulation on the presynaptic inhibition by alpha-adrenoceptor stimulation of the adrenergic transmission

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7 January 2021

Evidence against adrenergic motor transmission in the guinea-pig vas deferens

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7 January 2021

Adrenergic and 'non-adrenergic' components in the contractile response of the vas deferens to a single indirect stimulus

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7 January 2021

The effects of alpha-adrenoceptor agonists and antagonists on responses of transmurally stimulated prostatic and epididymal portions of the isolated vas deferens of the rat

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7 January 2021

Separation of adrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens

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7 January 2021

The Schild regression in the process of receptor classification

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7 January 2021

Antagonism of noradrenaline and histamine by desipramine in the isolated artery of the rabbit ear.

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7 January 2021

Alpha-noradrenergic receptor binding in mammalian brain: Differential labeling of agonist and antagonist states

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

3HPara-amino-clonidine: A novel ligand which binds with high affinity to α-adrenergic receptors

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7 January 2021

Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Binding of the imidazoline UK-14, 304, a putative full α2-adrenoceptor agonist, to rat cerebral cortex membranes

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7 January 2021

Radioligand Binding Studies of Adrenergic Receptors: New Insights into Molecular and Physiological Regulation

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7 January 2021

Human platelet α2-adrenergic receptors: Labeling with 3H-yohimbine, a selective antagonist ligand

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7 January 2021

3Hrauwolscine and 3Hyohimbine binding to rat cerebral and human platelet membranes: Possible heterogeneity of α2-adrenoceptors

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7 January 2021

3Hrauwolscine (α-yohimbine): A specific antagonist radioligand for brain α2-adrenergic receptors

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7 January 2021

3HRX 781094: A new antagonist ligand labels α2-adrenoceptors in the rat brain cortex

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7 January 2021

The effects of metal ions on the binding of a new alpha 2-adrenoceptor antagonist radioligand (3H)-RX 781094 in rat cerebral cortex.

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7 January 2021

Evidence for pharmacological similarity between alpha 2-adrenoceptors in the vas deferens and central nervous system of the rat.

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7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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7 January 2021

Presynaptic Receptors

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7 January 2021

Mini-review. The postsynaptic alpha 2-adrenoreceptor

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7 January 2021

Presynaptic Alpha-Receptor Subsensitivity After Long-Term Antidepressant Treatment

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7 January 2021

Feedback Inhibition of Brain Noradrenaline Neurons by Tricyclic Antidepressants: α-Receptor Mediation

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7 January 2021

Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment

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7 January 2021

Effects of acutely and chronically administered antidepressants on the clonidine-induced decrease in rat brain 3-methoxy-4-hydroxyphenylethylene-glycol sulphate content

1 reference

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7 January 2021

Effects of chronic desipramine treatment on rat brain noradrenergic responses to α-adrenergic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Interaction of antidepressants with clonidine on rat brain total 3-methoxy-4-hydroxyphenylglycol

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Presynaptic adrenergic receptor sensitivity in depression. The effect of long-term desipramine treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Presynaptic noradrenergic regulation during depression and antidepressant drug treatment

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Pharmacological properties of some "second generation" antidepressant drugs

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Mode of action of antidepressant drugs

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Rapid desensitization of cerebral cortical beta-adrenergic receptors induced by desmethylimipramine and phenoxybenzamine

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Acceleration of β-receptor desensitization in combined administration of antidepressants and phenoxybenzamine

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Neural control of the endocrine pancreas

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

? 2-Adrenoceptors modulating insulin release from isolated pancreatic islets

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Characterization of physiological agonist selectivity of human fat cell alpha 2-adrenoceptors: adrenaline is the major stimulant of the alpha 2-adrenoceptors

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7 January 2021

Why do people get fat?

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7 January 2021

Dietary Sodium and Renal α2-Adrenergic Receptors in Dahl Hypertensive Rats

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7 January 2021

Aggregation of blood platelets by biogenic amines and its inhibition by antiadrenergic and antiserotoninergic agents

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7 January 2021

The influence of drugs on disseminated intravascular coagulation (DIC) V. Effects of α-adrenoceptor blocking agents on thrombin-induced DIC in rats

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7 January 2021

Nonhormonal Pharmacological Treatment of Organic Impotence

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7 January 2021

Preferential blockade of presynaptic α-adrenoceptors by yohimbine

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7 January 2021

Pharmacological and biochemical properties of isomeric yohimbine alkaloids

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7 January 2021

Binding of yohimbine stereoisomers to α-adrenoceptors in rat liver and human platelets

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7 January 2021

Antagonist/agonist-preferring alpha-adrenoceptors or alpha 1/alpha 2-adrenoceptors?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Characterization of alpha-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Functional characterization of central α-adrenoceptors by yohimbine diastereomers

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit

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7 January 2021

Studies on the relationship between chemical constitution and physiological action: Molecular dissymmetry and physiological activity

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7 January 2021

Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness

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7 January 2021

The pharmacology of mianserin-an update

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Blockade of presynaptic ?-receptors and of amine uptake in the rat brain by the antidepressant mianserine

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7 January 2021

Presynaptic alpha-adrenoceptor blocking properties among tri- and tetra-cyclic antidepressant drugs

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7 January 2021

The tetracyclic antidepressant mianserin: evaluation of its blockade of presynaptic alpha-adrenoceptors in a self-stimulation model using clonidine

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7 January 2021

Effects of (+)- and (−)-Mianserin on α-adrenoceptors and tyramine-induced tachycardia in rats

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7 January 2021

Mianserin — An analysis of its peripheral autonomic actions

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7 January 2021

Comparison of mianserin with desipramine, maprotiline and phentolamine on cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors and noradrenaline reuptake in pithed normotensive rats

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

An examination of factors influencing adrenergic transmission in the pithed rat, with special reference to noradrenaline uptake mechanisms and post-junctional ?-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Evaluation of the selectivity of alpha-adrenoreceptor blocking drugs for postsynaptic alpha 1- and alpha 2-adrenoreceptors in a simple animal model

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Presynaptic α-block and inhibition of noradrenaline and 5-hydroxytryptamine reuptake by a series of compounds related to mianserin

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Comparative pharmacology of mianserin, its main metabolites and 6-azamianserin.

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7 January 2021

CGS 7525A, A new, centrally active alpha2 adrenoceptor antagonist

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7 January 2021

.alpha.-Adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic .alpha.2-adrenoreceptor antagonists and potential antidepressants

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

2-Alkyl analogues of idazoxan (RX 781094) with enhanced antagonist potency and selectivity at central α2-adrenoceptors in the rat

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Selectivity and potency of 2-alkyl analogues of the α2-adrenoceptor antagonist idazoxan (RX 781094) in peripheral systems

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

.alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Studies on RX 781094: a selective, potent and specific antagonist of α2-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Comparison of the ?-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

α1-Adrenoceptor agonist activity of α2-adrenoceptor antagonists in the pithed rat preparation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Partial agonist effect of 2-[2-(1,4-benzodioxanyl)]-2-imidazoline (RX 781 094) at presynaptic alpha 2-adrenoceptors in rabbit ear artery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Electrophysiological demonstration of both α2-agonist and antagonist properties of RX 781094

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

synthesis and antihypertensive activity of 2-sulfonamido- and 2-sulfamido-1,3,4,6,7,11b alpha-hexahydro-2H-benzo[a]quinolizines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Studies of the α2-adrenoceptor affinity and the α2- to α1-adrenoceptor selectivity of some substituted benzoquinolizines using receptor-binding techniques

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Alpha2-adrenoceptor antagonism and other pharmacological antagonist properties of some substituted benzoquinolizines and yohimbine in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The alpha 2-adrenoceptor selectivities and haemodynamic effects of WY26392 and yohimbine in the anaesthetised dog.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The effect of yohimbine, WY 26392 and idazoxan on sympathetic nerve activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

An investigation into the selectivity of a novel series of benzoquinolizines for alpha 2-adrenoceptors in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Seasonal variations in drug response and staircase phenomena in atrial muscle from a hibernating rodent (Spermophilus richardsonii)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Cyclic guanidines. X. Synthesis of 2-(2,2-disubstituted ethenyl- and ethyl)-2-imidazolines as potent hypoglycemics

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Comparative study on the effects of a hypoglycemic 2-substituted-2-imidazoline derivative (DG-5128) and tolbutamide on insulin secretion from and insulin synthesis in the isolated rat pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Insulin releasing action of 2-[2-(4,5-dihydro-1H-imadazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128), a new, orally effective hypoglycaemic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The selectivity of DG-5128 as an α2-adrenoceptor antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Selective interaction of DG-5128 with a low agonist affinity state of alpha-2 adrenoceptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Piperazinylimidazo[1,2-a]pyrazines with selective affinity for in vitro .alpha.-adrenergic receptor subtypes

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Pyridinylpiperazines, a new class of selective .alpha.2-adrenoceptor antagonists

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7 January 2021

Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The blockade of α2-adrenoceptors by the PNMT inhibitor SK&F 64139

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

alpha 2 Adrenoreceptor affinity of some inhibitors of norepinephrine N-methyltransferase.

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Lowering of blood pressure in hypertensive rats by SKF 64139 and SKF 72223

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine: a potent and selective antagonist of .alpha.2-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The ocular hypotensive action of SK&F 86466 in the conscious rabbit

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https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The effect of selective α1- and α2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Affinity chromatography of human platelet alpha 2-adrenergic receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Development of an affinity ligand for purification of .alpha.2-adrenoceptors from human platelet membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

In vitro selectivity of lisuride and other ergot derivatives for alpha 1- and alpha 2-adrenoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Stereospecific blockade of α2-adrenoceptors by (+)-butaclamol: implications for the characterization of dopamine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Action of local hormones: remarks on chemical specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

The preferred conformation of noradrenaline and a consideration of alpha-adrenergic receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Quantum mechanical study of the conformational properties of phenethylamines of biochemical and medicinal interest

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Stereochemical requirements of α2-adrenergic receptors for α-methyl substituted phenethylamines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

Differences in the applicability of the easson-stedman hypothesis to the alpha 1- and alpha 2-adrenergic effects of phenethylamines and imidazolines

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6468%2808%2970339-4

7 January 2021

10.1016/S0079-6468(08)70339-4

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