(Q39466096)

12 September 2017

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Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. (English)

1 reference

12 September 2017

Proarrhythmic defects in Timothy Syndrome require calmodulin kinase II (English)

1 reference

18 February 2022

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William H Thiel

1

1 reference

12 September 2017

Biyi Chen

2

1 reference

12 September 2017

Thomas J Hund

3

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12 September 2017

Olha M Koval

4

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12 September 2017

Anil Purohit

5

1 reference

12 September 2017

Long-Sheng Song

6

1 reference

12 September 2017

Peter J Mohler

7

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12 September 2017

Mark E Anderson

8

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12 September 2017

William Howard Thiel

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dissertation submitted to

18 February 2022

Vanderbilt University

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18 February 2022

language of work or name

English

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18 February 2022

publication date

10 November 2008

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12 September 2017

2008

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full work available at URL

18 February 2022

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18 February 2022

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12 September 2017

118

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12 September 2017

22

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12 September 2017

2225-2234

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The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Orphaned ryanodine receptors in the failing heart.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Imaging microdomain Ca2+ in muscle cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Cardiac excitation-contraction coupling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Calmodulin kinase is a molecular switch for cardiac excitation-contraction coupling

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

RETRACTED: L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3226825

Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms

1 October 2018

1 reference

12 December 2020

Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase

1 reference

12 December 2020

Multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca(2+)-induced enhancement of the L-type Ca2+ current in rabbit ventricular myocytes

1 reference

12 December 2020

CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes

1 reference

12 December 2020

Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation

1 reference

12 December 2020

Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current

1 reference

12 December 2020

Calmodulin kinase II inhibition protects against structural heart disease

1 reference

12 December 2020

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes

1 reference

12 December 2020

Calmodulin kinase II inhibition shortens action potential duration by upregulation of K+ currents

1 reference

12 December 2020

CaM kinase augments cardiac L-type Ca2+ current: a cellular mechanism for long Q-T arrhythmias

1 reference

12 December 2020

Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes

1 reference

12 December 2020

Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79

1 reference

12 December 2020

Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban

1 reference

12 December 2020

Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L-type Ca2+ current in rabbit cardiomyocytes

1 reference

12 December 2020

10.1161/CIRCULATIONAHA.108.788067

Identifiers

DOI

1 reference

12 September 2017

1 reference

18 February 2022

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12 September 2017

PubMed publication ID

19001023

1 reference