(Q39476739)

12 September 2017

title

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design (English)

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12 September 2017

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10

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12 September 2017

8

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Frank J Dekker

2

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author name string

Christian Hedberg

1

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12 September 2017

Marion Rusch

3

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12 September 2017

Steffen Renner

4

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12 September 2017

Stefan Wetzel

5

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12 September 2017

Nachiket Vartak

6

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12 September 2017

Claas Gerding-Reimers

7

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12 September 2017

Philippe I H Bastiaens

9

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12 September 2017

language of work or name

English

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publication date

9 September 2011

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Angewandte Chemie International Edition

12 September 2017

published in

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volume

50

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12 September 2017

issue

42

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12 September 2017

page(s)

9832-9837

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Ras proteins: different signals from different locations

12 September 2017

cites work

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Therapeutic intervention based on protein prenylation and associated modifications

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Lipidated ras and rab peptides and proteins--synthesis, structure, and function

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

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Small-molecule inhibition of APT1 affects Ras localization and signaling

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The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

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Protein acyl thioesterases (Review).

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Compound library development guided by protein structure similarity clustering and natural product structure

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Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.

21 January 2018

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Bioactivity-guided navigation of chemical space

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

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Biology-inspired synthesis of compound libraries

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Regiospecificity and catalytic triad of lysophospholipase I.

21 January 2018

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Cloning, expression, and catalytic mechanism of murine lysophospholipase I.

21 January 2018

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Purification and properties of lysophospholipase isoenzymes from pig gastric mucosa

21 January 2018

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Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1.

21 January 2018

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A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

21 January 2018

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

21 January 2018

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Lysophospholipase I identified as a ghrelin deacylation enzyme in rat stomach

21 January 2018

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Enzymatic depalmitoylation of viral glycoproteins with acyl-protein thioesterase 1 in vitro

21 January 2018

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Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

21 January 2018

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Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A

21 January 2018

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Boron-mediated aldol reaction of carboxylic esters: complementary anti- and syn-selective asymmetric aldol reactions

21 January 2018

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Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening

21 January 2018

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MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

21 January 2018

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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

21 January 2018

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N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

21 January 2018

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Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201102965

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12 September 2017

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