(Q39481309)

English

Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

12 September 2017

Anti-neoplastic agent thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts (English)

1 reference

Europe PubMed Central

12 September 2017

author name string

Mahmoud Alhosin

1

1 reference

Europe PubMed Central

12 September 2017

Abdulkhaleg Ibrahim

2

1 reference

Europe PubMed Central

12 September 2017

Abdelaziz Boukhari

3

1 reference

Europe PubMed Central

12 September 2017

Tanveer Sharif

4

1 reference

Europe PubMed Central

12 September 2017

Jean-Pierre Gies

5

1 reference

Europe PubMed Central

12 September 2017

Cyril Auger

6

1 reference

Europe PubMed Central

12 September 2017

Valérie B Schini-Kerth

7

1 reference

Europe PubMed Central

12 September 2017

publication date

1 September 2011

1 reference

Europe PubMed Central

12 September 2017

Investigational New Drugs

1 reference

Europe PubMed Central

12 September 2017

30

1 reference

Europe PubMed Central

12 September 2017

5

1 reference

Europe PubMed Central

12 September 2017

1813-1819

1 reference

Europe PubMed Central

12 September 2017

https://scigraph.springernature.com/pub.10.1007/s10637-011-9734-1

0 references

Targeting microtubules for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Microtubules as a target for anticancer drugs

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Microtubule-binding agents: a dynamic field of cancer therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Tubulin: a target for antineoplastic drugs into the cancer cells but also in the peripheral nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Peripheral nerve damage associated with administration of taxanes in patients with cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

A study of toxicity and comparative therapeutic efficacy of vindesine-prednisone vs. vincristine-prednisone in children with acute lymphoblastic leukemia in relapse. A Pediatric Oncology Group study

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Phase III trial of vinflunine plus best supportive care compared with best supportive care alone after a platinum-containing regimen in patients with advanced transitional cell carcinoma of the urothelial tract

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Review on molecular and therapeutic potential of thymoquinone in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Thymoquinone: a promising anti-cancer drug from natural sources

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Role of the newer p53 family proteins in malignancy

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

p73: Friend or foe in tumorigenesis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

PPARgamma Inhibitors as Novel Tubulin-Targeting Agents

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

BUB1 mediation of caspase-independent mitotic death determines cell fate

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Caspase-independent mitotic death (CIMD).

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

The microtubule-targeting agent T0070907 induces proteasomal degradation of tubulin

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactions

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-011-9734-1

21 January 2018

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21881916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21881916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21881916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MDM2 antagonist nutlin-3 sensitizes p53-null neuroblastoma cells to doxorubicin via E2F1 and TAp73.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21881916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/21881916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10637-011-9734-1

1 reference

Europe PubMed Central

12 September 2017

1 reference

Europe PubMed Central

12 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39481309&oldid=1830370910"