(Q39490146)

12 September 2017

title

Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells (English)

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12 September 2017

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Jurate Savickiene

1

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12 September 2017

Grazina Treigyte

2

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12 September 2017

Violeta Jonusiene

3

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12 September 2017

Renata Bruzaite

4

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12 September 2017

Veronika-Viktorija Borutinskaite

5

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12 September 2017

Ruta Navakauskiene

6

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12 September 2017

publication date

13 August 2011

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Molecular and Cellular Biochemistry

12 September 2017

published in

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12 September 2017

volume

359

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12 September 2017

issue

1-2

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12 September 2017

page(s)

245-261

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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

12 September 2017

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21 January 2018

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The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

21 January 2018

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Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

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Methylation profiling in acute myeloid leukemia.

21 January 2018

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Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

21 January 2018

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DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.

21 January 2018

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KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients.

21 January 2018

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Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines.

21 January 2018

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CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer

21 January 2018

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Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications

21 January 2018

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

21 January 2018

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Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

21 January 2018

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Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase

21 January 2018

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Inhibition of DNA methylation and reactivation of silenced genes by zebularine

21 January 2018

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Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy

21 January 2018

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Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells

21 January 2018

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Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.

21 January 2018

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Promoter analysis of epigenetically controlled genes in bladder cancer.

21 January 2018

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Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

21 January 2018

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Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation

21 January 2018

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The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines

21 January 2018

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Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors

21 January 2018

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Preferential response of cancer cells to zebularine.

21 January 2018

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Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Selective variegated methylation of the p15 CpG island in acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Cadherins in development: cell adhesion, sorting, and tissue morphogenesis

21 January 2018

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Histone acetylation in chromatin structure and transcription

21 January 2018

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Histone methylation in transcriptional control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone 1 1Edited by J. Karn

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-011-1019-7

Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance

21 January 2018

1 reference

12 December 2020

E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.

1 reference

12 December 2020

Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia

1 reference

12 December 2020

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1 reference

12 December 2020

DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action

1 reference

12 December 2020

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine

1 reference

12 December 2020

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies

1 reference

12 December 2020

Activation of expression of p15, p73 and E-cadherin in leukemic cells by different concentrations of 5-aza-2'-deoxycytidine (Decitabine).

1 reference

12 December 2020

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

1 reference

12 December 2020

p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing

1 reference

12 December 2020

Promoter hypermethylation analysis in myelodysplastic syndromes: diagnostic & prognostic implication.

1 reference

12 December 2020

Chromatin remodeling and leukemia: new therapeutic paradigms.

1 reference

12 December 2020

Hypermethylation of E-cadherin in leukemia

1 reference

12 December 2020

p15 (INK4B) and E-cadherin CpG island methylation is frequent in Egyptian acute myeloid leukemia

1 reference

12 December 2020

Alterations in DNA methylation: a fundamental aspect of neoplasia

1 reference

12 December 2020

Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia

1 reference

12 December 2020

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.

1 reference

12 December 2020

Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia

1 reference

12 December 2020

A systematic profile of DNA methylation in human cancer cell lines

1 reference

12 December 2020

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

1 reference

12 December 2020

10.1007/S11010-011-1019-7

Identifiers

DOI

1 reference

12 September 2017

1 reference