(Q39499295)

12 September 2017

Anti-tumor activity of the HSP90 inhibitor SNX-2112 in pediatric cancer cell lines (English)

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12 September 2017

Danielle C Chinn

1

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12 September 2017

William S Holland

2

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12 September 2017

Janet M Yoon

3

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12 September 2017

Theodore Zwerdling

4

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12 September 2017

Philip C Mack

5

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12 September 2017

language of work or name

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27 July 2011

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12 September 2017

Pediatric Blood Cancer

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12 September 2017

58

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12 September 2017

6

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12 September 2017

885-890

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Targets for cancer therapy in childhood sarcomas

12 September 2017

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Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

21 January 2018

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Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

21 January 2018

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The Hsp90 chaperone machinery

21 January 2018

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Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

21 January 2018

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Targeting the dynamic HSP90 complex in cancer

21 January 2018

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Heat shock protein 90 as a drug target: some like it hot.

21 January 2018

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Targeting heat shock proteins in cancer

21 January 2018

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Update on Hsp90 inhibitors in clinical trial.

21 January 2018

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Development of Radicicol Analogues

21 January 2018

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SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

21 January 2018

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SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

21 January 2018

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Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice

21 January 2018

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Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth

21 January 2018

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

21 January 2018

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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

21 January 2018

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Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation

21 January 2018

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Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket

21 January 2018

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Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

21 January 2018

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The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

21 January 2018

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Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma

21 January 2018

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Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition

21 January 2018

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HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo

21 January 2018

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Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

21 January 2018

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An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

21 January 2018

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90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.

21 January 2018

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Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

21 January 2018

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Continuous or repeated prolonged cisplatin infusions in children: a prospective study on ototoxicity, platinum concentrations, and standard serum parameters

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PBC.23270

1 reference

release_njapxi2krfbjxfplpzh7d64gsa

12 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/njapxi2krfbjxfplpzh7d64gsa

mapped directly with Wikidata item

24 November 2022

based on heuristic

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