(Q39500664)

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Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction

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Europe PubMed Central

PubMed publication ID

12 September 2017

Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

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hepatocellular carcinoma

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based on heuristic

inferred from title

author name string

Irena Manov

1

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Yulia Pollak

2

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Rinata Broneshter

3

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Theodore C Iancu

4

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Europe PubMed Central

PubMed publication ID

12 September 2017

language of work or name

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publication date

1 September 2011

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Europe PubMed Central

PubMed publication ID

12 September 2017

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Europe PubMed Central

PubMed publication ID

12 September 2017

278

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Europe PubMed Central

PubMed publication ID

12 September 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

3494-3507

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

Novel advancements in the management of hepatocellular carcinoma in 2008.

1 reference

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21 January 2018

A randomized phase III study of doxorubicin versus cisplatin/interferon alpha-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma.

1 reference

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21 January 2018

Dysregulation of apoptosis in hepatocellular carcinoma cells

1 reference

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From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now.

1 reference

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Targeting the RAF-MEK-ERK pathway in cancer therapy

1 reference

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21 January 2018

Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma

1 reference

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21 January 2018

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

1 reference

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21 January 2018

Sorafenib in advanced hepatocellular carcinoma

1 reference

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Safety and anti-tumor activity of sorafenib (Nexavar) in combination with other anti-cancer agents: a review of clinical trials

1 reference

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21 January 2018

Multimodal approaches to the treatment of hepatocellular carcinoma

1 reference

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Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial

1 reference

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21 January 2018

Combination of sorafenib and doxorubicin in patients with advanced hepatocellular carcinoma: results from a phase I extension trial.

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ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

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A death-promoting role for extracellular signal-regulated kinase

1 reference

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Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis

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21 January 2018

High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway.

1 reference

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21 January 2018

ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes

1 reference

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21 January 2018

Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells

1 reference

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Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo

1 reference

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21 January 2018

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

1 reference

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21 January 2018

Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors.

1 reference

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21 January 2018

A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

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21 January 2018

Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells

1 reference

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21 January 2018

Maturation of autophagic vacuoles in Mammalian cells

1 reference

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Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells

1 reference

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The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

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21 January 2018

A dual role of p53 in the control of autophagy

1 reference

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21 January 2018

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

1 reference

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21 January 2018

Tumour cell survival signalling by the ERK1/2 pathway

1 reference

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21 January 2018

The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin

1 reference

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21 January 2018

Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation

1 reference

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21 January 2018

Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK.

1 reference

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Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

1 reference

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Autophagy as a cell death and tumor suppressor mechanism

1 reference

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Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?

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Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

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Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells.

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Spatial analysis of key signaling proteins by high-content solid-phase cytometry in Hep3B cells treated with an inhibitor of Cdc25 dual-specificity phosphatases

1 reference

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21 January 2018

Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death

1 reference

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Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity

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Differences in effects on myocardium and mitochondria by angiogenic inhibitors suggest separate mechanisms of cardiotoxicity

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The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.

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Regulation of DNA fragmentation: the role of caspases and phosphorylation

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Sensory neurons with activated caspase-3 survive long-term experimental diabetes

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Autophagy in cell death: an innocent convict?

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MEK/ERK signaling is a critical mediator for integrin-induced cell scattering in highly metastatic hepatocellular carcinoma cells

1 reference

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21 January 2018

Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells

1 reference

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21 January 2018

Involvement of the multidrug resistance P-glycoprotein in acetaminophen-induced toxicity in hepatoma-derived HepG2 and Hep3B cells.

1 reference

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21 January 2018

Identifiers

10.1111/J.1742-4658.2011.08271.X

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 September 2017

ResearchGate publication ID

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