(Q39501449)

English

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

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scholarly article

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Europe PubMed Central

12 September 2017

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways (English)

1 reference

Europe PubMed Central

12 September 2017

apoptotic process

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author name string

Radhamani Kannaiyan

1

1 reference

Europe PubMed Central

12 September 2017

Kanjoormana Aryan Manu

2

1 reference

Europe PubMed Central

12 September 2017

Luxi Chen

3

1 reference

Europe PubMed Central

12 September 2017

Feng Li

4

1 reference

Europe PubMed Central

12 September 2017

Peramaiyan Rajendran

5

1 reference

Europe PubMed Central

12 September 2017

Aruljothi Subramaniam

6

1 reference

Europe PubMed Central

12 September 2017

Paula Lam

7

1 reference

Europe PubMed Central

12 September 2017

Alan Prem Kumar

8

1 reference

Europe PubMed Central

12 September 2017

Gautam Sethi

9

1 reference

Europe PubMed Central

12 September 2017

publication date

1 October 2011

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Europe PubMed Central

12 September 2017

1 reference

Europe PubMed Central

12 September 2017

16

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Europe PubMed Central

12 September 2017

10

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Europe PubMed Central

12 September 2017

1028-1041

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Europe PubMed Central

12 September 2017

https://scigraph.springernature.com/pub.10.1007/s10495-011-0629-6

0 references

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Cancer prevention with natural compounds

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Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

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Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.

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Celastrol: Molecular targets of Thunder God Vine

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Celastrol: a new therapeutic potential of traditional Chinese medicine

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Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

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Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation

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Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors

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Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway

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Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.

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Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

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The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

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Potential pharmacological control of the NF-κB pathway

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Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

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A method for detecting Shiga toxin and Shiga-like toxin-I in pure and mixed culture.

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Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

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Apoptosis-targeted therapies for cancer

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Exploring death receptor pathways as selective targets in cancer therapy

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Apoptosis signaling

1 reference

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Apoptosis-based therapies

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

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Tumor necrosis factor: an apoptosis JuNKie?

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The c-jun kinase/stress-activated pathway: regulation, function and role in human disease

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Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.

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The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease

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Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

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Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo

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Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

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Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

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Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines

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Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase

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Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.

1 reference

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Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning

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Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

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Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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AKT/PKB signaling: navigating downstream

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Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

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Role of JNK activation in apoptosis: a double-edged sword

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JNK signaling in apoptosis

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Nuclear cyclin D1: an oncogenic driver in human cancer

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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death

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JNK/SAPK activity contributes to TRAIL-induced apoptosis

1 reference

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

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Identifiers

10.1007/S10495-011-0629-6

1 reference

Europe PubMed Central

12 September 2017

release_wohdaopkivgizizged3prlm4nu

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1 reference

Europe PubMed Central

12 September 2017

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