(Q39504273)

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Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway

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Europe PubMed Central

PMC publication ID

12 September 2017

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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author name string

J-M Zheng

1

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

J-M Zhu

2

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

L-S Li

3

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Europe PubMed Central

PMC publication ID

12 September 2017

Z-H Liu

4

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Europe PubMed Central

PMC publication ID

12 September 2017

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publication date

11 February 2008

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Europe PubMed Central

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12 September 2017

British Journal of Pharmacology

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Europe PubMed Central

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12 September 2017

153

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Europe PubMed Central

PMC publication ID

12 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

1456-1464

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

Hyperglycemia and glucosamine-induced mesangial cell cycle arrest and hypertrophy: Common or independent mechanisms?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Cell cycle control in breast cancer cells

1 reference

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12 September 2017

Growth factor regulation of cell cycle progression in mammary epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

The importance of diabetic nephropathy in current nephrological practice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

The relationship between glucose control and the development and progression of diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Identification of a biochemical link between energy intake and energy expenditure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Biochemistry and molecular cell biology of diabetic complications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Cell cycle regulation in diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Role of the glucosamine pathway in fat-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Structural-functional relationships in diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Coordinated regulation of glutamine:fructose-6-phosphate amidotransferase activity by insulin, glucose, and glutamine. Role of hexosamine biosynthesis in enzyme regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

12 September 2017

Induction of macrophage glutamine: fructose-6-phosphate amidotransferase expression by hypoxia and by picolinic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

14 September 2017

A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

14 September 2017

High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

14 September 2017

Vascular permeability in diabetics and implications for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

14 September 2017

Glomerular cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

14 September 2017

Hexosamines and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

25 September 2017

D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells: implications for diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

25 September 2017

Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

25 September 2017

Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

25 September 2017

Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

TGF-beta 1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

The relationship between glucose control and the development of diabetic nephropathy in type I diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

15 June 2018

Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Combining TGF-beta inhibition and angiotensin II blockade results in enhanced antifibrotic effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Angiotensin II activates the GFAT promoter in mesangial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor beta in rat mesangial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Sequential effects of high glucose on mesangial cell transforming growth factor-beta 1 and fibronectin synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2437903

21 August 2018

Effect of lonidamine and rhein on the phosphorylation potential generated by respiring rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane-associated functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of emodin on c-myc proto-oncongen expression in cultured rat mesangial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diacetylrhein and rhein: in vivo and in vitro effect on lymphocyte membrane fluidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18264122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJP.2008.26

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

release_hpbvt5yoabdl3jsfwjcz6gbydq

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

ResearchGate publication ID

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