(Q39511082)

12 September 2017

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator (English)

1 reference

12 September 2017

18

1 reference

12 September 2017

Hairuo Peng

1

1 reference

12 September 2017

Tina Talreja

2

1 reference

12 September 2017

Zhili Xin

3

1 reference

12 September 2017

J Hernan Cuervo

4

1 reference

12 September 2017

Gnanasambandam Kumaravel

5

1 reference

12 September 2017

Michael J Humora

6

1 reference

12 September 2017

Lin Xu

7

1 reference

12 September 2017

Ellen Rohde

8

1 reference

12 September 2017

Lawrence Gan

9

1 reference

12 September 2017

Mi-Young Jung

10

1 reference

12 September 2017

Melanie N Shackett

11

1 reference

12 September 2017

Sowmya Chollate

12

1 reference

12 September 2017

Anthone W Dunah

13

1 reference

12 September 2017

Pamela A Snodgrass-Belt

14

1 reference

12 September 2017

H Moore Arnold

15

1 reference

12 September 2017

Arthur G Taveras

16

1 reference

12 September 2017

Kenneth J Rhodes

17

1 reference

12 September 2017

5 August 2011

1 reference

ACS Medicinal Chemistry Letters

12 September 2017

1 reference

12 September 2017

2

1 reference

12 September 2017

10

1 reference

12 September 2017

786-791

1 reference

γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Alzheimer's disease: strategies for disease modification

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

The secretases: enzymes with therapeutic potential in Alzheimer disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Deciphering the molecular basis of memory failure in Alzheimer's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Delta-1 activation of notch-1 signaling results in HES-1 transactivation.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4018072

Fluorinated piperidine acetic acids as gamma-secretase modulators

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900267

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML200175Q

1 reference

12 September 2017

1 reference

12 September 2017

PubMed publication ID

24900267

1 reference