(Q39531156)

English

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.

scientific article published on 3 June 2011

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2 February 2020

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity (English)

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Karl-Norbert Klotz

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Sebastian F M Häusler

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2 February 2020

Itsaso Montalbán del Barrio

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Jenny Strohschein

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P Anoop Chandran

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Arnd Hönig

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Monika Ossadnik

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Evi Horn

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Birgitt Fischer

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Mathias Krockenberger

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Stefan Heuer

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Ahmed Adel Seida

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Markus Junker

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Hermann Kneitz

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Doris Kloor

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Johannes Dietl

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Jörg Wischhusen

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3 June 2011

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Cancer Immunology, Immunotherapy

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1405-1418

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2 February 2020

https://scigraph.springernature.com/pub.10.1007/s00262-011-1040-4

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A2A adenosine receptor protects tumors from antitumor T cells.

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Adenosine: an endogenous regulator of innate immunity

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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

1 reference

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21 January 2018

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

1 reference

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21 January 2018

Ecto-enzyme and signaling functions of lymphocyte CD73

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Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function.

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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

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Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas

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Selective NTPDase2 expression modulates in vivo rat glioma growth

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Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

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Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal.

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Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D.

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DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.

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A rapid method for determining ATP by the firefly luciferin-luciferase system

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A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity

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A noncommercial dual luciferase enzyme assay system for reporter gene analysis

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Pharmacological and biochemical analysis of FPL 67156, a novel, selective inhibitor of ecto-ATPase

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21 January 2018

Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors

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Biophotonic cytotoxicity assay for high-throughput screening of cytolytic killing

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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

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The role of CD26/dipeptidyl peptidase IV in cancer

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HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia

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21 January 2018

Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells

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21 January 2018

Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer

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21 January 2018

Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors

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21 January 2018

Deletion of cd39/entpd1 results in hepatic insulin resistance

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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

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Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease

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Identifiers

10.1007/S00262-011-1040-4

1 reference

Europe PubMed Central

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2 February 2020

1 reference

Europe PubMed Central

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2 February 2020

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